Goolden A W, Kam K C, Fitzpatrick M L, Munro A J
Br J Radiol. 1986 Jun;59(702):583-6. doi: 10.1259/0007-1285-59-702-583.
Six out of 30 patients who underwent thyroid ablation with 131I during the period 1975-85 developed acute oedema of the neck within 48 h of the therapeutic dose. The condition was painless and responded well to treatment with corticosteroids. The early onset and absence of pain distinguish this complication from radiation thyroiditis. Dosage calculations and thermoluminescent-dosimeter measurements of the dose at various points on the anterior surface of the neck of a patient with a toxic adenoma of the thyroid treated with 131I were in fairly good agreement with one another and confirmed that the oedema of the neck could not be a direct effect of irradiation on the extrathyroidal tissues. It is suggested that this phenomenon may be a hypersensitivity reaction associated with massive destruction of thyroid tissue.
在1975年至1985年期间接受131I甲状腺消融治疗的30例患者中，有6例在给予治疗剂量后的48小时内出现颈部急性水肿。这种情况无痛，对皮质类固醇治疗反应良好。早期发作且无疼痛将这种并发症与放射性甲状腺炎区分开来。对一名患有毒性甲状腺腺瘤并接受131I治疗的患者颈部前表面不同点的剂量进行剂量计算和热释光剂量计测量，结果彼此相当吻合，并证实颈部水肿不可能是辐射对甲状腺外组织的直接影响。有人提出，这种现象可能是与甲状腺组织大量破坏相关的超敏反应。
