Kunnumakkara Ajaikumar B, Hegde Mangala, Parama Dey, Girisa Sosmitha, Kumar Aviral, Daimary Uzini Devi, Garodia Prachi, Yenisetti Sarat Chandra, Oommen Oommen V, Aggarwal Bharat B
Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam-781039, India.
Integrative Research Center, Miami, Florida 33125, United States.
ACS Pharmacol Transl Sci. 2023 Mar 6;6(4):447-518. doi: 10.1021/acsptsci.2c00012. eCollection 2023 Apr 14.
Turmeric () has been used for thousands of years for the prevention and treatment of various chronic diseases. Curcumin is just one of >200 ingredients in turmeric. Almost 7000 scientific papers on turmeric and almost 20,000 on curcumin have been published in PubMed. Scientific reports based on cell culture or animal studies are often not reproducible in humans. Therefore, human clinical trials are the best indicators for the prevention and treatment of a disease using a given agent/drug. Herein, we conducted an extensive literature survey on PubMed and Scopus following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The keywords "turmeric and clinical trials" and "curcumin and clinical trials" were considered for data mining. A total of 148 references were found to be relevant for the key term "turmeric and clinical trials", of which 70 were common in both PubMed and Scopus, 44 were unique to PubMed, and 34 were unique to Scopus. Similarly, for the search term "curcumin and clinical trials", 440 references were found to be relevant, of which 70 were unique to PubMed, 110 were unique to Scopus, and 260 were common to both databases. These studies show that the golden spice has enormous health and medicinal benefits for humans. This Review will extract and summarize the lessons learned about turmeric and curcumin in the prevention and treatment of chronic diseases based on clinical trials.
姜黄已被用于预防和治疗各种慢性疾病达数千年之久。姜黄素只是姜黄中200多种成分之一。在PubMed上已发表了近7000篇关于姜黄的科学论文以及近20000篇关于姜黄素的科学论文。基于细胞培养或动物研究的科学报告在人体中往往无法重复。因此，人体临床试验是使用特定药物预防和治疗疾病的最佳指标。在此，我们按照系统评价和Meta分析的首选报告项目指南，在PubMed和Scopus上进行了广泛的文献调查。考虑使用关键词“姜黄与临床试验”和“姜黄素与临床试验”进行数据挖掘。共发现148篇参考文献与关键词“姜黄与临床试验”相关，其中70篇在PubMed和Scopus中都有，44篇是PubMed独有的，34篇是Scopus独有的。同样，对于搜索词“姜黄素与临床试验”，发现440篇参考文献相关，其中70篇是PubMed独有的，110篇是Scopus独有的，260篇是两个数据库共有的。这些研究表明，这种金色香料对人类具有巨大的健康和药用益处。本综述将基于临床试验提取并总结在预防和治疗慢性疾病方面关于姜黄和姜黄素的经验教训。
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