Dragoș Dorin, Enache Iulia I, Manea Maria M
Faculty of Medicine, Department 1-Medical Semiology, Nephrology-Bucharest Emergency University Hospital, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Doctoral School, Faculty of Medicine, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Antioxidants (Basel). 2025 Jun 20;14(7):757. doi: 10.3390/antiox14070757.
Oxidative stress is a key component in the pathogenesis of a broad number of renal disorders, including acute kidney injury, chronic kidney disease, and various types of nephropathies. Moreover, oxidative stress seems to at least partly explain the intricate relationship the kidney has with other pathological entities, for instance with cardiovascular comorbidities. Renal replacement therapies give end-stage renal disease patients a fighting chance; however, even these interventions may carry the risk of enhancing existing oxidative stress. Even if nutritional components are not currently routinely used, many have shown promise in preclinical or even clinical studies and could counter some of the deleterious pathways that oxidative stress sets in place. This narrative review provides an update on how these natural nutrients could be beneficial to renal disease patients, and it also aims to give an incentive to future research in the field.
氧化应激是众多肾脏疾病发病机制中的关键因素，包括急性肾损伤、慢性肾脏病以及各类肾病。此外，氧化应激似乎至少部分解释了肾脏与其他病理实体之间的复杂关系，例如与心血管合并症的关系。肾脏替代疗法为终末期肾病患者提供了一线生机；然而，即便这些干预措施也可能存在加剧现有氧化应激的风险。尽管目前营养成分并非常规使用，但许多营养成分已在临床前甚至临床研究中展现出前景，并且能够对抗氧化应激引发的一些有害途径。这篇叙述性综述提供了关于这些天然营养素如何有益于肾病患者的最新信息，同时旨在激励该领域未来的研究。
