绿茶对超重和肥胖女性血脂谱的影响。

Effects of green tea on lipid profile in overweight and obese women.

机构信息

Department of Cardiovascular Medicine, The First Affiliated Hospital of Jiamusi University, Jiamusi, China.

Cardiac Catheterization Room, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

出版信息

Int J Vitam Nutr Res. 2024 Jun;94(3-4):239-251. doi: 10.1024/0300-9831/a000783. Epub 2023 Apr 21.

DOI:10.1024/0300-9831/a000783

PMID:37082776

Abstract

The effect of green tea administration on serum lipids' concentrations remains unclear as various investigations, which have explored this topic, have produced conflicting results. Gender might be one of the factors influencing the impact of green tea on the lipid profile. Hence, we conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effect of green tea intake on the lipid profile in overweight and obese women. We searched five databases (Web of Science, SCOPUS, Embase, PubMed/Medline, and Google Scholar) using a combination of MeSH and non-MeSH terms. Results were expressed as weighted mean differences (WMDs) and 95% confidence intervals (CIs) and synthesized with a random-effects model. In total, 15 eligible RCTs with 16 arms (1818 participants) were included in the meta-analysis. The combined effect size revealed a significant reduction in total cholesterol (TC) (WMD: -4.45 mg/dl, 95% CI: -6.63, -2.27, P<0.001) and low-density lipoprotein cholesterol (LDL-C) (WMD: -4.49 mg/dl, 95% CI: -7.50 to -1.47, P=0.003) concentrations following green tea supplementation in overweight and/or obese women. In addition, a more pronounced reduction of triglyceride (TG) levels occurred when the baseline TG value was ≥150 mg/dL (WMD: -24.45 mg/dL, 95% CI: -40.63 to -8.26, P=0.003). Moreover, a significant decrease in TG concentrations occurred in RCTs conducted on overweight subjects (BMI: 25-29.99 kg/m) (WMD: -5.88 mg/dl, 95% CI: -10.76 to -0.99, P=0.01). In the subgroup analyses based on the study population, a notable increase in high-density lipoprotein cholesterol (HDL-C) values was observed in obese individuals (>30 kg/m) (WMD: 2.63 mg/dl, 95% CI: 0.10 to 5.16, P=0.041). Consumption of green tea causes a reduction in LDL-C and TC concentrations in overweight and obese women. The decline in TG levels was notable particularly in overweight patients with hypertriglyceridemia at baseline. In addition, a significant increase in HDL-C was detected in obese subjects following intake of green tea.

摘要

绿茶对血清脂质浓度的影响尚不清楚，因为各种探讨这一主题的研究得出了相互矛盾的结果。性别可能是影响绿茶对血脂谱影响的因素之一。因此，我们进行了一项系统评价和荟萃分析，以评估超重和肥胖女性摄入绿茶对血脂谱的影响。我们使用 MeSH 和非 MeSH 术语的组合，在五个数据库（Web of Science、SCOPUS、Embase、PubMed/Medline 和 Google Scholar）中进行了搜索。结果表示为加权均数差（WMD）和 95%置信区间（CI），并采用随机效应模型进行综合。共有 15 项符合条件的 RCT（16 个臂，1818 名参与者）纳入荟萃分析。合并的效应大小显示，总胆固醇（TC）（WMD：-4.45mg/dl，95%CI：-6.63，-2.27，P<0.001）和低密度脂蛋白胆固醇（LDL-C）（WMD：-4.49mg/dl，95%CI：-7.50 至-1.47，P=0.003）浓度显著降低。此外，当基线 TG 值≥150mg/dL 时，甘油三酯（TG）水平的降低更为明显（WMD：-24.45mg/dL，95%CI：-40.63 至-8.26，P=0.003）。此外，在针对超重受试者（BMI：25-29.99kg/m）的 RCT 中，TG 浓度显著降低（WMD：-5.88mg/dl，95%CI：-10.76 至-0.99，P=0.01）。基于研究人群的亚组分析显示，肥胖者（>30kg/m）的高密度脂蛋白胆固醇（HDL-C）值显著升高（WMD：2.63mg/dl，95%CI：0.10 至 5.16，P=0.041）。绿茶的摄入导致超重和肥胖女性的 LDL-C 和 TC 浓度降低。TG 水平的下降尤其在基线时伴有高甘油三酯血症的超重患者中明显。此外，摄入绿茶后肥胖者的 HDL-C 显著增加。