Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Phytother Res. 2024 Jan;38(1):241-252. doi: 10.1002/ptr.8046. Epub 2023 Oct 21.
This systematic review aimed to gather data on the effects of sumac supplementation on lipid profile. A systematic literature search was carried out using electronic databases (PubMed, Scopus, and Web of Science) up to March 2023 to identify eligible randomized controlled trials (RCTs) assessing the effects of sumac intake on lipid profile as an outcome. All participants enrolled in our study were adult individuals who consumed sumac, in various forms, as an intervention. The included articles were assessed using the Cochrane risk of bias assessment tool. Heterogeneity tests of the selected trials were performed using the I statistic. Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as the weighted mean difference with a 95% confidence interval. In total, seven RCTs with a total sample size of 570 subjects were included. This study found a significant decrease in total cholesterol (TC) (weighted mean difference [WMD]: -10.01 mg/dL; 95% CI: -18.67, -1.34), triglyceride (TG) (WMD: -8.52 mg/dL; 95% CI: -14.79, -2.25), and low-density lipoprotein (LDL)-C levels (WMD: -9.25 mg/dL; 95% CI: -14.56, -3.93); Moreover, a significant increase was observed in high-density lipoprotein (HDL)-C concentration (WMD: 2.97 mg/dL; 95% CI: 0.75, 5.19). The reduction in TG and TC was greater in studies with a duration of ≥12 compared to <12 weeks. The increase in HDL-C was greater in participants with an intervention duration of ≥12 compared to <12 weeks. Moreover, subgroup analysis based on the dose of sumac suggested a significant reduction in TC and LDL, specifically for doses below 3 g. Consumption of sumac significantly decreased serum TC, LDL-C, and TG concentrations. This study suggested significantly positive effects on HDL-C by intake of sumac. Longer interventions (>12 weeks) have a more favorable impact on TC, LDL-C, and HDL-C, while sumac doses below 3 g/day show greater effects on TC and LDL-C. These findings underscore the potential of sumac supplementation as a valuable approach to lipid profile management.
本系统评价旨在收集有关 sumac 补充剂对血脂谱影响的数据。使用电子数据库（PubMed、Scopus 和 Web of Science）进行了系统文献检索，截至 2023 年 3 月，以确定评估 sumac 摄入对血脂谱影响的合格随机对照试验（RCT）。我们研究中的所有参与者均为成年个体，以各种形式摄入 sumac 作为干预措施。使用 Cochrane 偏倚风险评估工具评估纳入的文章。使用 I 统计量对选定试验进行异质性检验。根据异质性检验评估了随机效应模型，并确定汇总数据为加权均数差和 95%置信区间。共有 7 项 RCT 纳入了 570 名受试者。本研究发现总胆固醇（TC）（加权均数差 [WMD]：-10.01mg/dL；95%CI：-18.67，-1.34）、三酰甘油（TG）（WMD：-8.52mg/dL；95%CI：-14.79，-2.25）和低密度脂蛋白胆固醇（LDL-C）水平（WMD：-9.25mg/dL；95%CI：-14.56，-3.93）显著降低；此外，高密度脂蛋白（HDL）-C 浓度（WMD：2.97mg/dL；95%CI：0.75，5.19）显著升高。与持续时间<12 周的研究相比，持续时间≥12 周的研究中 TG 和 TC 的降低更为明显。与持续时间<12 周的研究相比，持续时间≥12 周的研究中 HDL-C 的增加更为明显。此外，基于 sumac 剂量的亚组分析表明，TC 和 LDL 显著降低，特别是剂量低于 3g。sumac 的摄入显著降低了血清 TC、LDL-C 和 TG 浓度。本研究表明，sumac 摄入对 HDL-C 有显著的积极影响。干预时间>12 周（>12 周）对 TC、LDL-C 和 HDL-C 的影响更为有利，而每天摄入 sumac 剂量低于 3g 时对 TC 和 LDL-C 的影响更大。这些发现强调了 sumac 补充剂作为一种管理血脂谱的有价值方法的潜力。
