Department of Dermatology, Rasoul Akram Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Department of Radiology, Iran University of Medical Sciences (IUMS), Tehran, Iran.
J Cosmet Dermatol. 2023 Oct;22(10):2714-2720. doi: 10.1111/jocd.15776. Epub 2023 Apr 21.
Acne vulgaris is a common skin disease that is more common in young population and it can be associated with some sequels after resolving the lesions. Post-inflammatory erythema is one of these complications that can be disturbing for patients and does not have any definite treatment. This study was aimed to evaluate the efficacy and safety of tranexamic acid (TA) as mesotherapy in treatment of post-acne erythema (PAE) treatment.
This clinical trial study was performed in the dermatology clinic on 17 patients with persistent PAE (3 months after acne recovery). Two sessions of treatment were performed by a physician with 2-week intervals; TA was injected as mesotherapy into the right side of each patient's face as the case group, while the opposite side was used as the control group. A Visioface device was used to compare before and after treatment photographs of each side of the face in color mode with quantitative measures such as lesions count, area, and area percent.
Finally, 15 patients completed treatment sessions. There were statistically significant differences in right side lesions before and after treatment with p-values of 0.047, 0.002, and 0.035 for count, area, and area percent, respectively. There was no significant difference before and after treatment in terms of count, area. and area-percent on the left side.
According to the results of this study, TA injection as mesotherapy for resolving PAE can be effective. However, due to small sample size, further studies are needed.
寻常痤疮是一种常见的皮肤病，多见于年轻人，皮损消退后可遗留一些后遗症。炎症后红斑是其中一种并发症，可使患者感到困扰，且目前尚无确切的治疗方法。本研究旨在评估氨甲环酸（TA）作为痤疮后红斑（PAE）治疗的微针疗法的疗效和安全性。
这是一项在皮肤科诊所进行的临床试验研究，纳入了 17 例持续性 PAE（痤疮痊愈后 3 个月）患者。由一名医生在 2 周的间隔内进行 2 次治疗；将 TA 作为微针疗法注射到每位患者面部的右侧作为实验组，而左侧作为对照组。使用 Visioface 设备以彩色模式比较面部两侧治疗前后的照片，并进行定量测量，如病变计数、面积和面积百分比。
最终，15 例患者完成了治疗疗程。治疗后右侧病变的计数、面积和面积百分比与治疗前相比均有统计学差异（p 值分别为 0.047、0.002 和 0.035）。而左侧病变的计数、面积和面积百分比在治疗前后无显著差异。
根据本研究结果，TA 注射作为微针疗法治疗 PAE 可能有效。但由于样本量小，还需要进一步的研究。
