Department of Dermatology, Rasoul Akram Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran.
General Practitioner, Mazandaran University of Medical Sciences, Mazandaran, Iran.
J Cosmet Dermatol. 2023 Sep;22(9):2548-2552. doi: 10.1111/jocd.15744. Epub 2023 Mar 28.
Tranexamic acid is used to treat pigmented disorder in dermatology for a long time however there are limited data for effectiveness of tranexamic acid for rejuvenation and improvement of wrinkle. Here we want to find the effectiveness of tranexamic acid as mesotherapy in improvement of periorbital wrinkle in a clinical trial study.
Patients with melasma who were treated with 4 session of tranexamic acid mesotherapy at intervals on 1 week were evaluated with Visioface device before starting and 1 month after last course of treatment. The outcomes including volume, area, area percent, and depth were measured by Visioface device.
Mean of periorbital wrinkles volume before and after procedure were 89 271 and 74 639 pixel (px ), respectively. Very significant difference with p-value of <0.001 was detected at volume of patient wrinkles before and after treatment. Moreover, the mean of area (and area percent) of their periorbital wrinkles before and after therapeutic method were 8481 Px (1.131%) and 7184 Px (0.646%), respectively, with significant differences (both have p-value of <0.001).Mean of periorbital wrinkles depth at before and after treatment were 9.8 and 9.6, respectively, without remarkable difference (p-value was 0.257).
Tranexamic acid mesotherapy significantly leads to reduced volume and area of wrinkles. Injection of tranexamic acid as mesotherapy seems to be effective in improvement of periorbital wrinkling.
氨甲环酸长期以来一直被用于皮肤科治疗色素性疾病，但对于氨甲环酸在皮肤年轻化和皱纹改善方面的有效性，数据有限。在这里，我们想通过临床试验研究来发现氨甲环酸作为微整形疗法在改善眶周皱纹方面的有效性。
接受 4 次氨甲环酸微整形治疗（间隔 1 周，共 4 个疗程）的黄褐斑患者，在开始治疗前和最后一次治疗后 1 个月，使用 Visioface 设备进行评估。使用 Visioface 设备测量体积、面积、面积百分比和深度等结果。
治疗前和治疗后患者眶周皱纹的平均体积分别为 89271 和 74639 像素（px）。治疗前后患者皱纹体积的差异非常显著（p 值<0.001）。此外，治疗前和治疗后眶周皱纹的平均面积（和面积百分比）分别为 8481px（1.131%）和 7184px（0.646%），差异具有统计学意义（两者的 p 值均<0.001）。治疗前后眶周皱纹的平均深度分别为 9.8 和 9.6，差异无统计学意义（p 值为 0.257）。
氨甲环酸微整形治疗可显著减少皱纹的体积和面积。氨甲环酸注射作为微整形疗法似乎对改善眶周皱纹有效。
