Department of Cardiology, Zhongda Hospital of Southeast University, Southeast University, Nanjing, China.
Department of Cardiology, Zhongda Hospital of Southeast University, Central Gate Street, Gulou District, Nanjing City, Jiangsu Province 210009, China.
Europace. 2023 May 19;25(5). doi: 10.1093/europace/euad102.
This study aims to explore the association between the features of epicardial adipose tissue (EAT) in different zones and premature ventricular complexes (PVCs) originating from different sites by computed tomography (CT).
A total of 136 patients who underwent radiofrequency ablation for PVCs were incorporated in this study. One hundred and thirty-six matched controls were included in this study using the case-control method (1:1 matching). PVCs were classified into four subgroups: (1) right ventricular outflow tract (RVOT-PVCs), (2) non-RVOT of the right ventricle (RV-PVCs), (3) left ventricular outflow tract (LVOT-PVCs), and (4) non-LVOT of the left ventricle (LV-PVCs). The volume and density of EAT were quantified by CT. Patients with PVCs had a significantly higher volume and lower density of EAT than the controls (P < 0.001). The LVOT-PVCs and LV-PVCs had a higher left ventricle periventricular EAT volume (LV-EATv) proportion (P < 0.05). The right ventricle periventricular EAT volume (RV-EATv) proportion was higher in ROVT-PVCs and LVOT-PVCs (P < 0.05). RVOT-PVC patients had a higher volume ratio and a smaller density differential (P < 0.05). Patients with LVOT-PVCs had a lower volume ratio and the LV-PVCs showed a greater density differential (P < 0.05).
Higher volume and lower density of EAT were significantly associated with frequent PVCs. The RVOT-PVC patients had a higher volume ratio and a smaller density differential. The LVOT-PVCs had a lower volume ratio and the LV-PVCs showed a greater density differential. These suggest a link between EAT structural properties and PVCs and a potential role for regional EAT in the development of PVCs.
本研究旨在通过计算机断层扫描（CT）探讨心外膜脂肪组织（EAT）不同区域特征与源自不同部位的室性早搏（PVCs）之间的关系。
本研究纳入了 136 例因 PVCs 而行射频消融术的患者。采用病例对照法（1:1 匹配）纳入了 136 例匹配的对照患者。通过 CT 定量分析 EAT 的体积和密度。与对照组相比，PVCs 患者的 EAT 体积更大，密度更低（P < 0.001）。左心室流出道（LVOT）-PVCs 和左心室非流出道（LV）-PVCs 的左心室心外膜周 EAT 体积（LV-EATv）比例更高（P < 0.05）。右心室流出道（RVOT）-PVCs 和 LVOT-PVCs 的右心室心外膜周 EAT 体积（RV-EATv）比例更高（P < 0.05）。RVOT-PVC 患者的体积比更高，密度差异更小（P < 0.05）。LVOT-PVC 患者的体积比更低，而 LV-PVCs 的密度差异更大（P < 0.05）。
EAT 体积更大、密度更低与频发 PVCs 显著相关。RVOT-PVC 患者的体积比更高，密度差异更小。LVOT-PVCs 的体积比更低，而 LV-PVCs 的密度差异更大。这表明 EAT 结构特性与 PVCs 之间存在关联，区域性 EAT 在 PVCs 的发生中可能发挥作用。
