Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Cambridge, United States.
Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, United States.
Elife. 2023 Apr 21;12:e76645. doi: 10.7554/eLife.76645.
Despite advances in high-dimensional cellular analysis, the molecular profiling of dynamic behaviors of cells in their native environment remains a major challenge. We present a method that allows us to couple the physiological behaviors of cells in an intact murine tissue to deep molecular profiling of individual cells. This method enabled us to establish a novel molecular signature for a striking migratory cellular behavior following injury in murine airways.
尽管在高维细胞分析方面取得了进展，但在其天然环境中对细胞动态行为进行分子分析仍然是一个主要挑战。我们提出了一种方法，使我们能够将完整的鼠组织中细胞的生理行为与单个细胞的深度分子分析相结合。这种方法使我们能够为损伤后鼠气道中明显的迁移细胞行为建立一个新的分子特征。
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