Resident Ophthalmologist, Layton Rahmatulla Benevolent Trust (LRBT) Tertiary Teaching Eye Hospital (Korangi), Karachi City, Pakistan.
Consultant Ophthalmologist, Uveitis, Layton Rahmatulla Benevolent Trust (LRBT) Tertiary Teaching Eye Hospital (Korangi), Karachi City, Pakistan.
Ocul Immunol Inflamm. 2024 Jul;32(5):707-712. doi: 10.1080/09273948.2023.2198598. Epub 2023 Apr 21.
This prospective experimental study was conducted on 40 eyes of 40 patients with complicated uveitic cataracts to compare a single intraoperative intravitreal injection of triamcinolone acetonide (IVTA) with oral steroids for inflammation control after cataract extraction.
The IVTA group (19 eyes) received an intravitreal injection of 4 mg/0.1 ml triamcinolone acetonide intraoperatively, and the oral steroid group (19 eyes) received oral steroids peri-operatively. Two patients had to be excluded from the study because they underwent extracapsular cataract extraction (ECCE), instead of phacoemulsification.
A statistically significant difference was observed in the anterior chamber cell and flare response between both groups initially, but by the last follow-up, this became insignificant. None of the patients in each group experienced a recurrence of uveitis nor developed cystoid macular edema. Five patients in the oral steroid group had IOP >21 mmHg post-operatively.
A single injection of 4 mg IVTA has similar efficacy to peri-operative oral steroid administration.
本前瞻性实验研究共纳入 40 例（40 只眼）复杂性葡萄膜炎并发性白内障患者，比较白内障摘出术后单眼玻璃体内注射曲安奈德（IVTA）与口服皮质类固醇治疗炎症的效果。
IVTA 组（19 只眼）术中玻璃体内注射 4mg/0.1ml 曲安奈德，口服皮质类固醇组（19 只眼）围手术期口服皮质类固醇。因施行白内障囊外摘出术（ECCE）而非超声乳化术，有 2 例患者被排除。
两组间最初在前房细胞和闪辉反应方面存在显著差异，但在最后一次随访时，这种差异变得无统计学意义。两组均无患者出现葡萄膜炎复发或发生黄斑囊样水肿。口服皮质类固醇组 5 例患者术后眼压>21mmHg。
单眼玻璃体内注射 4mg IVTA 的疗效与围手术期口服皮质类固醇相当。
