Nohr C W, Fairfull-Smith R, Christou N V
Can J Surg. 1986 May;29(3):194-7.
The authors evaluated the host-defence capability of a 33-year-old woman with a history of poor wound healing, gastrointestinal fistulas and bacterial and fungal sepsis after abdominal operations. The following tests gave normal results: hemoglobin, blood neutrophil and monocyte counts, delayed hypersensitivity skin test, serum albumin, immunoglobulin and complement levels, blood T- and B-cell percentages, in-vitro immunoglobulin synthesis and body cell mass. The following tests gave abnormal results: lymphocyte count, leukocyte adherence, in-vivo and in-vitro polymorphonuclear neutrophil chemotaxis, neutrophil bacterial killing and antibody response to tetanus toxoid. Decreased polymorphonuclear neutrophil and humoral immune functions could account for the woman's history of repeated surgical sepsis. Evaluation of host-defence mechanisms can illuminate the cause of repeated episodes of sepsis.
作者对一名33岁女性的宿主防御能力进行了评估，该女性有腹部手术后伤口愈合不良、胃肠道瘘以及细菌和真菌败血症病史。以下检查结果正常：血红蛋白、血液中性粒细胞和单核细胞计数、迟发型超敏皮肤试验、血清白蛋白、免疫球蛋白和补体水平、血液T细胞和B细胞百分比、体外免疫球蛋白合成以及体细胞质量。以下检查结果异常：淋巴细胞计数、白细胞黏附、体内和体外多形核中性粒细胞趋化性、中性粒细胞杀菌能力以及对破伤风类毒素的抗体反应。多形核中性粒细胞和体液免疫功能降低可解释该女性反复发生手术败血症的病史。对宿主防御机制的评估可以阐明败血症反复发作的原因。
