inhibited the methylation of to suppress the progression of PC by targeting .

Pancreatic cancer (PC) is one of the deadliest malignancies, with poor diagnosis and prognosis. has been reported to be a tumor suppressor in various cancers, whereas the mechanism of in the progression of PC remains poorly understood. In this study, it was found that and were down-regulated, whereas was up-regulated in PC. Knockdown of or overexpression of suppressed PC cell proliferation, invasion, and migration, as well as tumor formation in nude mice. DNMT3A induced the methylation of promoter. knockdown reversed the inhibiting effect of silencing on PC cell growth. directly bound to and negatively regulated its expression while up-regulating levels. overexpression reversed the inhibiting effect of overexpression on PC cell growth. In conclusion, the overexpression of could suppress proliferation, invasion, and migration of PC cells, as well as tumor formation in nude mice through inhibiting the methylation of by targeting .