Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy.
Center for Cardiovascular Research, Department of Cardiology, Charité-Universitätsmedizin Berlin, Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany; Translational Approaches in Heart Failure and Cardiometabolic Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany; Division of Cardiology, Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
JACC Heart Fail. 2023 Jun;11(6):637-645. doi: 10.1016/j.jchf.2023.02.007. Epub 2023 Apr 19.
Energy substrate metabolism and contractile function are tightly coupled in the heart. Within this framework, heart failure may be viewed as a state of impaired energy transfer. The metabolic changes in the failing heart are linked to functional and structural changes. A worthwhile goal is to measure metabolic flux and its regulation quantitatively, and to do this in a manner that leads to targeted interventions. For several good reasons, this goal has been elusive until now. The development of new analytical and imaging techniques offers the potential of exploring the landscape of metabolic changes across the different stages of heart failure. In this Review Topic of the Month, the authors focus on concepts and brevity to provide a strategic overview of cardiac metabolism in the diagnosis, prevention, and treatment of nonischemic heart failure.
能量底物代谢和收缩功能在心脏中紧密偶联。在这个框架内，心力衰竭可以被视为能量传递受损的状态。衰竭心脏的代谢变化与功能和结构变化有关。一个有价值的目标是定量测量代谢通量及其调节，并以能够进行靶向干预的方式来实现这一目标。由于几个很好的原因，到目前为止，这个目标一直难以实现。新的分析和成像技术的发展为探索心力衰竭不同阶段代谢变化的全貌提供了潜力。在本月的综述专题中，作者关注概念和简洁性，为非缺血性心力衰竭的诊断、预防和治疗提供心脏代谢的战略概述。
