Faculty of Medicine, Department of Psychiatry, Tekirdağ Namık Kemal University, Tekirdağ Namık Kemal Üniversitesi Tıp Fakültesi 59100, Süleymanpaşa, Tekirdağ, Turkey.
Faculty of Medicine, Department of Biochemistry, Tekirdağ Namık Kemal University, Tekirdağ, Turkey.
Eur Arch Psychiatry Clin Neurosci. 2024 Apr;274(3):515-524. doi: 10.1007/s00406-023-01607-9. Epub 2023 Apr 22.
The progression of bipolar disorder (BD) is characterized by recurrent episodes of depression, mania, and hypomania, thus affecting the daily functionality of individuals. Previous studies have shown that a large proportion of patients diagnosed with BD who are in clinical remission experience significant functional disorders. The present study aimed to investigate the relationships between cognitive impairment and serum progesterone, allopregnanolone and BDNF levels in male bipolar disorder patients who are in the euthymic period. Our study included 41 euthymic male patients with bipolar disorder and 40 age, sex, body mass index (BMI) and smoking-matched male healthy control subjects. Neuropsychiatric tests such as the Stroop Test TBAG Form, Auditory Verbal Digit Span Test- Form B (VADS-B) and Cancellation Test were administered to all participants, and 5-7 ml of peripheral venous blood sample was taken from all participants. Serum allopregnanolone, progesterone and BDNF levels were also measured in all participants. Serum allopregnanolone and progesterone levels were found to be lower in bipolar patients, and it was observed that the serum level of allopregnanolone decreased as the disease duration increased. The serum BDNF levels were similar between groups. The cognitive functions assessed using the Stroop, VADS-B and cancellation tests were found to be better in healthy subjects. The neurocognitive test performances of all participants were strongly positively correlated with allopregnanolone levels. The present study supports the hypothesis that allopregnanolone acts as an endogenous mood stabilizer.
双相障碍（BD）的进展特点是反复发作的抑郁、躁狂和轻躁狂，从而影响个体的日常功能。先前的研究表明，很大一部分处于临床缓解期的 BD 患者经历着显著的功能障碍。本研究旨在探讨处于缓解期的男性双相障碍患者认知障碍与血清孕激素、别孕烯醇酮和脑源性神经营养因子（BDNF）水平之间的关系。本研究纳入了 41 名处于缓解期的男性双相障碍患者和 40 名年龄、性别、体重指数（BMI）和吸烟相匹配的男性健康对照者。所有参与者都进行了神经心理测试，如 Stroop 测试 TBAG 形式、听觉言语数字跨度测试-形式 B（VADS-B）和删除测试，并且从所有参与者中抽取 5-7ml 外周静脉血样。所有参与者的血清别孕烯醇酮、孕激素和 BDNF 水平也进行了测量。结果发现，双相患者的血清别孕烯醇酮和孕激素水平较低，并且随着疾病持续时间的增加，血清别孕烯醇酮水平下降。组间血清 BDNF 水平相似。使用 Stroop、VADS-B 和删除测试评估的认知功能在健康受试者中更好。所有参与者的神经认知测试表现与别孕烯醇酮水平呈强烈正相关。本研究支持别孕烯醇酮作为内源性情绪稳定剂的假说。
