Department of Dairy Science, University of Wisconsin-Madison, Madison, WI, USA.
Departments of Orthopedics and Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Sci Rep. 2019 Jan 18;9(1):238. doi: 10.1038/s41598-018-36497-8.
Selective Serotonin Reuptake Inhibitors (SSRIs) such as fluoxetine are widely prescribed to pregnant and breastfeeding women, yet the effects of peripartum SSRI exposure on neonatal bone are not known. In adult populations, SSRI use is associated with compromised bone health, and infants exposed to in utero SSRIs have a smaller head circumference and are shorter, suggesting possible effects on longitudinal growth. Yet no study to date has examined the effects of peripartum SSRIs on long bone growth or mass. We used microCT to determine the outcomes of in utero and lactational SSRI exposure on C57BL6 pup bone microarchitecture. We found that peripartum exposure to 20 mg/kg fluoxetine reduced femoral bone mineral density and bone volume fraction, negatively impacted trabecular and cortical parameters, and resulted in shorter femurs on postnatal day 21. Although SSRIs are considered the first-choice antidepressant for pregnant and lactating women due to a low side effect profile, SSRI exposure may compromise fetal and neonatal bone development.
选择性 5-羟色胺再摄取抑制剂（SSRIs），如氟西汀，被广泛用于治疗孕妇和哺乳期妇女，但围产期 SSRI 暴露对新生儿骨骼的影响尚不清楚。在成年人群中，SSRIs 的使用与骨骼健康受损有关，而在子宫内暴露于 SSRIs 的婴儿头围较小，身高较矮，这表明可能对纵向生长有影响。然而，迄今为止，尚无研究探讨围产期 SSRIs 对长骨生长或质量的影响。我们使用 microCT 来确定围产期暴露于 20mg/kg 氟西汀对 C57BL6 幼崽骨骼微观结构的影响。我们发现，围产期暴露于 20mg/kg 氟西汀会降低股骨骨密度和骨体积分数，对小梁和皮质参数产生负面影响，并导致出生后第 21 天股骨变短。尽管由于副作用低，SSRIs 被认为是治疗孕妇和哺乳期妇女的首选抗抑郁药，但 SSRIs 的暴露可能会损害胎儿和新生儿的骨骼发育。
