Department of Dermatology, Yale School of Medicine, New Haven, CT, USA.
The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA; The Jackson Laboratory Cancer Center, Bar Harbor, ME, USA.
Trends Cancer. 2023 Jul;9(7):578-590. doi: 10.1016/j.trecan.2023.03.009. Epub 2023 Apr 20.
Realizing the clinical promise of cancer immunotherapy is hindered by gaps in our knowledge of in vivo mechanisms underlying treatment response as well as treatment limiting toxicity. Preclinical in vivo model systems and technologies are required to address these knowledge gaps and to surmount the challenges faced in the clinical application of immunotherapy. Mice are commonly used for basic and translational research to support development and testing of immune interventions, including for cancer. Here, we discuss the advantages and the limitations of current models as well as future developments.
实现癌症免疫疗法的临床承诺受到我们对治疗反应以及限制治疗毒性的体内机制的知识差距的阻碍。需要临床前体内模型系统和技术来解决这些知识差距，并克服免疫疗法临床应用中面临的挑战。老鼠通常用于基础和转化研究，以支持免疫干预措施的开发和测试，包括癌症。在这里，我们讨论了当前模型的优缺点以及未来的发展。
