Neuroscience Research Australia, Sydney, New South Wales, Australia.
University of New South Wales, Sydney, New South Wales, Australia.
Alzheimers Dement. 2023 Nov;19(11):4999-5009. doi: 10.1002/alz.13082. Epub 2023 Apr 23.
The Dominantly Inherited Alzheimer Network (DIAN) is a longitudinal observational study that collects data on cognition, blood pressure (BP), and other variables from autosomal-dominant Alzheimer's disease mutation carriers (MCs) and non-carrier (NC) family members in early to mid-adulthood, providing a unique opportunity to evaluate BP and cognition relationships in these populations.
We examined cross-sectional and longitudinal relationships between systolic and diastolic BP and cognition in DIAN MC and NC.
Data were available from 528 participants, who had a mean age of 38 (SD = 11) and were 42% male and 61% MCs, at a median follow-up of 2 years. Linear-multilevel models found only cross-sectional associations in the MC group between higher systolic BP and poorer performance on language (β = -0.181 [-0.318, -0.044]), episodic memory (-0.212 [-0.375, -0.049]), and a composite cognitive measure (-0.146 [-0.276, -0.015]). In NCs, the relationship was cross-sectional only and present for language alone.
Higher systolic BP was cross-sectionally but not longitudinally associated with poorer cognition, particularly in MCs. BP may influence cognition gradually, but further longitudinal research is needed.
显性遗传性阿尔茨海默病网络（DIAN）是一项纵向观察性研究，从常染色体显性阿尔茨海默病突变携带者（MC）和非携带者（NC）的成年早期到中期收集认知、血压（BP）和其他变量的数据，为评估这些人群中的 BP 和认知关系提供了独特的机会。
我们检查了 DIAN MC 和 NC 中收缩压和舒张压与认知的横断面和纵向关系。
共有 528 名参与者的数据可用，他们的平均年龄为 38 岁（标准差=11），男性占 42%，MC 占 61%，中位随访时间为 2 年。线性多层模型仅在 MC 组中发现收缩压较高与语言表现较差（β=-0.181[-0.318，-0.044]）、情景记忆（-0.212[-0.375，-0.049]）和综合认知测量（-0.146[-0.276，-0.015]）之间存在横断面关联。在 NC 中，这种关系仅为横断面关系，仅与语言有关。
较高的收缩压与认知较差呈横断面相关，但与认知无纵向相关，尤其是在 MC 中。BP 可能会逐渐影响认知，但需要进一步的纵向研究。
