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C反应蛋白与中性粒细胞：功能效应及复杂摄取

CRP and neutrophils: functional effects and complex uptake.

作者信息

Shephard E G, Anderson R, Strachan A F, Kühn S H, De Beer F C

出版信息

Clin Exp Immunol. 1986 Mar;63(3):718-27.

PMID:3708910
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1577559/
Abstract

The uptake of C-reactive protein (CRP)-pneumococcal C-polysaccharide (CPS) complexes by neutrophils was studied. A specific CRP dependent mechanism of uptake was demonstrated. This promoted CPS (complexed to CRP) clearance which was further enhanced by additional complement activation. Physiological concentrations of low density lipoprotein inhibited entry of complexed CPS into neutrophils but had no effect on entry of CRP alone. Pure human CRP was shown to have no effect on neutrophil chemotaxis and oxidative metabolism.

摘要

研究了中性粒细胞对C反应蛋白（CRP）-肺炎球菌C多糖（CPS）复合物的摄取。证实了一种依赖CRP的特异性摄取机制。这促进了（与CRP复合的）CPS的清除，额外的补体激活进一步增强了这种清除。生理浓度的低密度脂蛋白抑制复合CPS进入中性粒细胞，但对单独的CRP进入没有影响。已表明纯人CRP对中性粒细胞趋化性和氧化代谢没有影响。

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本文引用的文献

1
Studies of acute phase protein. I. An immunohistochemical method for the localization of Cx-reactive protein in rabbits. Association with necrosis in local inflammatory lesions.急性期蛋白的研究。I. 兔体内C反应蛋白定位的免疫组织化学方法。与局部炎症病变中坏死的关联。
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Studies of acute-phase protein. II. Localization of Cx-reactive protein in heart in induced myocardial infarction in rabbits.急性期蛋白的研究。II. 兔实验性心肌梗死时心脏中C反应蛋白的定位。
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In vitro effects of C-reactive protein on phagocytosis.C反应蛋白对吞噬作用的体外效应。
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Preparative and quantitative isolation of plasma lipoproteins: rapid, single discontinuous density gradient ultracentrifugation in a vertical rotor.血浆脂蛋白的制备与定量分离：在垂直转子中进行快速单步不连续密度梯度超速离心法
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Binding reactivity of C-reactive protein for polycations. II. Modulatory effects of calcium and phosphocholine.C反应蛋白对聚阳离子的结合反应性。II. 钙和磷酸胆碱的调节作用。
J Immunol. 1981 Oct;127(4):1509-14.
6
Effect of C-reactive protein on the complement-mediated stimulated of human neutrophils by Streptococcus pneumoniae serotypes 3 and 6.C反应蛋白对肺炎链球菌3型和6型血清型介导的人中性粒细胞补体激活的影响。
Infect Immun. 1982 Sep;37(3):987-92. doi: 10.1128/iai.37.3.987-992.1982.
7
C-reactive protein and serum amyloid P component in the plaice (Pleuronectes platessa L.), a marine teleost, are homologous with their human counterparts.鲽（鲽属，欧洲比目鱼）这种海洋硬骨鱼中的C反应蛋白和血清淀粉样P成分与其人类对应物同源。
Biochim Biophys Acta. 1982 May 21;704(1):123-33. doi: 10.1016/0167-4838(82)90139-x.
8
Low density lipoprotein and very low density lipoprotein are selectively bound by aggregated C-reactive protein.低密度脂蛋白和极低密度脂蛋白被聚集的C反应蛋白选择性结合。
J Exp Med. 1982 Jul 1;156(1):230-42. doi: 10.1084/jem.156.1.230.
9
Isolation of human C-reactive protein and serum amyloid P component.人C反应蛋白和血清淀粉样蛋白P成分的分离
J Immunol Methods. 1982;50(1):17-31. doi: 10.1016/0022-1759(82)90300-3.
10
A role for C-reactive protein in the complement-mediated stimulation of human neutrophils by type 27 Streptococcus pneumoniae.C反应蛋白在27型肺炎链球菌补体介导的人中性粒细胞刺激中的作用。
J Immunol. 1982 Jun;128(6):2493-6.