C反应蛋白与中性粒细胞：功能效应及复杂摄取
CRP and neutrophils: functional effects and complex uptake.
作者信息
Shephard E G, Anderson R, Strachan A F, Kühn S H, De Beer F C
出版信息
Clin Exp Immunol. 1986 Mar;63(3):718-27.
Abstract
The uptake of C-reactive protein (CRP)-pneumococcal C-polysaccharide (CPS) complexes by neutrophils was studied. A specific CRP dependent mechanism of uptake was demonstrated. This promoted CPS (complexed to CRP) clearance which was further enhanced by additional complement activation. Physiological concentrations of low density lipoprotein inhibited entry of complexed CPS into neutrophils but had no effect on entry of CRP alone. Pure human CRP was shown to have no effect on neutrophil chemotaxis and oxidative metabolism.
摘要
研究了中性粒细胞对C反应蛋白（CRP）-肺炎球菌C多糖（CPS）复合物的摄取。证实了一种依赖CRP的特异性摄取机制。这促进了（与CRP复合的）CPS的清除，额外的补体激活进一步增强了这种清除。生理浓度的低密度脂蛋白抑制复合CPS进入中性粒细胞，但对单独的CRP进入没有影响。已表明纯人CRP对中性粒细胞趋化性和氧化代谢没有影响。
相似文献
1
CRP and neutrophils: functional effects and complex uptake.C反应蛋白与中性粒细胞：功能效应及复杂摄取
Clin Exp Immunol. 1986 Mar;63(3):718-27.
2
3
4
5
6
Peptides derived from C-reactive protein inhibit neutrophil alveolitis.源自C反应蛋白的肽可抑制中性粒细胞性肺泡炎。
J Immunol. 1996 May 1;156(9):3412-7.
7
Transgenic mice expressing rabbit C-reactive protein exhibit diminished chemotactic factor-induced alveolitis.表达兔C反应蛋白的转基因小鼠表现出趋化因子诱导的肺泡炎减轻。
Am J Respir Crit Care Med. 1996 Mar;153(3):1141-7. doi: 10.1164/ajrccm.153.3.8630558.
8
Native and modified C-reactive protein bind different receptors on human neutrophils.天然和修饰的C反应蛋白与人中性粒细胞上的不同受体结合。
Int J Biochem Cell Biol. 2005 Feb;37(2):320-35. doi: 10.1016/j.biocel.2004.07.002.
9
Neutrophil lysosomal degradation of human CRP: CRP-derived peptides modulate neutrophil function.中性粒细胞对人CRP的溶酶体降解：CRP衍生肽调节中性粒细胞功能。
Clin Exp Immunol. 1988 Jul;73(1):139-45.
10
Effects of low-density lipoproteins on polymorphonuclear leukocyte functions in vitro.
J Lipid Mediat Cell Signal. 1994 Sep;10(3):203-12.
引用本文的文献
1
Local Production of Acute Phase Proteins: A Defense Reaction of Cancer Cells to Injury with Focus on Fibrinogen.局部产生急性期蛋白：癌细胞对损伤的防御反应，重点是纤维蛋白原。
Int J Mol Sci. 2024 Mar 19;25(6):3435. doi: 10.3390/ijms25063435.
2
A biofunctional review of C-reactive protein (CRP) as a mediator of inflammatory and immune responses: differentiating pentameric and modified CRP isoform effects.C-反应蛋白（CRP）作为炎症和免疫反应介质的生物功能综述：区分五聚体和修饰型 CRP 同工型的作用。
Front Immunol. 2023 Sep 15;14:1264383. doi: 10.3389/fimmu.2023.1264383. eCollection 2023.
3
Neutrophil lysosomal degradation of human CRP: CRP-derived peptides modulate neutrophil function.中性粒细胞对人CRP的溶酶体降解：CRP衍生肽调节中性粒细胞功能。
Clin Exp Immunol. 1988 Jul;73(1):139-45.
4
Binding sites for C-reactive protein on human monocytes are distinct from IgG Fc receptors.人单核细胞上C反应蛋白的结合位点与IgG Fc受体不同。
Immunology. 1989 May;67(1):51-5.
5
Stimulation of human neutrophils, monocytes, and platelets by modified C-reactive protein (CRP) expressing a neoantigenic specificity.表达新抗原特异性的修饰C反应蛋白对人中性粒细胞、单核细胞和血小板的刺激作用。
Inflammation. 1988 Aug;12(4):391-405. doi: 10.1007/BF00915774.
6
Binding of human C-reactive protein to monocytes: analysis by flow cytometry.人C反应蛋白与单核细胞的结合：流式细胞术分析
Clin Exp Immunol. 1991 May;84(2):329-35. doi: 10.1111/j.1365-2249.1991.tb08169.x.
7
C-reactive protein in patients with lymphatic filariasis: increased expression on lymphocytes in chronic lymphatic obstruction.淋巴丝虫病患者的C反应蛋白：在慢性淋巴阻塞时淋巴细胞上的表达增加。
J Clin Immunol. 1991 Jan;11(1):46-53. doi: 10.1007/BF00918794.
8
Pentraxin binding to isolated rat liver nuclei.五聚素与分离的大鼠肝细胞核的结合
Biochem J. 1991 Oct 1;279 ( Pt 1)(Pt 1):257-62. doi: 10.1042/bj2790257.
本文引用的文献
1
Studies of acute phase protein. I. An immunohistochemical method for the localization of Cx-reactive protein in rabbits. Association with necrosis in local inflammatory lesions.急性期蛋白的研究。I. 兔体内C反应蛋白定位的免疫组织化学方法。与局部炎症病变中坏死的关联。
J Exp Med. 1961 Dec 1;114(6):961-74. doi: 10.1084/jem.114.6.961.
2
Studies of acute-phase protein. II. Localization of Cx-reactive protein in heart in induced myocardial infarction in rabbits.急性期蛋白的研究。II. 兔实验性心肌梗死时心脏中C反应蛋白的定位。
J Clin Invest. 1963 Feb;42(2):286-92. doi: 10.1172/JCI104715.
3
In vitro effects of C-reactive protein on phagocytosis.C反应蛋白对吞噬作用的体外效应。
J Bacteriol. 1962 May;83(5):1017-24. doi: 10.1128/jb.83.5.1017-1024.1962.
4
5
Binding reactivity of C-reactive protein for polycations. II. Modulatory effects of calcium and phosphocholine.C反应蛋白对聚阳离子的结合反应性。II. 钙和磷酸胆碱的调节作用。
J Immunol. 1981 Oct;127(4):1509-14.
6
Effect of C-reactive protein on the complement-mediated stimulated of human neutrophils by Streptococcus pneumoniae serotypes 3 and 6.C反应蛋白对肺炎链球菌3型和6型血清型介导的人中性粒细胞补体激活的影响。
Infect Immun. 1982 Sep;37(3):987-92. doi: 10.1128/iai.37.3.987-992.1982.
7
C-reactive protein and serum amyloid P component in the plaice (Pleuronectes platessa L.), a marine teleost, are homologous with their human counterparts.鲽（鲽属，欧洲比目鱼）这种海洋硬骨鱼中的C反应蛋白和血清淀粉样P成分与其人类对应物同源。
Biochim Biophys Acta. 1982 May 21;704(1):123-33. doi: 10.1016/0167-4838(82)90139-x.
8
Low density lipoprotein and very low density lipoprotein are selectively bound by aggregated C-reactive protein.低密度脂蛋白和极低密度脂蛋白被聚集的C反应蛋白选择性结合。
J Exp Med. 1982 Jul 1;156(1):230-42. doi: 10.1084/jem.156.1.230.
9
Isolation of human C-reactive protein and serum amyloid P component.人C反应蛋白和血清淀粉样蛋白P成分的分离
J Immunol Methods. 1982;50(1):17-31. doi: 10.1016/0022-1759(82)90300-3.
Zotero 插件