纳洛酮对豚鼠哇巴因诱导的心脏毒性的预防及逆转作用
Prevention and reversal of ouabain-induced cardiotoxicity by naloxone in the guinea-pig.
作者信息
Lee A Y, Unang T W, Wong T M
出版信息
Clin Exp Pharmacol Physiol. 1986 Jan;13(1):55-8. doi: 10.1111/j.1440-1681.1986.tb00315.x.
The effects of pre- and post-treatment with naloxone on the cardiotoxicity of ouabain in the guinea-pig were studied. After pretreatment with naloxone, the dose of ouabain required to induce ventricular arrhythmias and cardiac arrest were significantly increased, in a dose-dependent manner, compared with the control, indicating a protective effect of naloxone against digitalis intoxication. Administration of naloxone at the onset of cardiac arrhythmias induced by a lethal dose of ouabain restored the cardiac rhythm and consequently saved life in seven out of eight animals, indicating an antiarrhythmic effect of naloxone in digitalis-intoxicated guinea-pigs. The protective and antiarrhythmic effects of naloxone against digitalis intoxication have clinical implications.
研究了纳洛酮预处理和后处理对豚鼠哇巴因心脏毒性的影响。与对照组相比，纳洛酮预处理后，诱导室性心律失常和心脏骤停所需的哇巴因剂量以剂量依赖性方式显著增加，表明纳洛酮对洋地黄中毒具有保护作用。在致死剂量哇巴因诱发心律失常开始时给予纳洛酮，可恢复八只动物中七只的心律，从而挽救生命，表明纳洛酮对洋地黄中毒的豚鼠具有抗心律失常作用。纳洛酮对洋地黄中毒的保护和抗心律失常作用具有临床意义。
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