Ryffel B, Müller A M, Mihatsch M J
Clin Nephrol. 1986;25 Suppl 1:S121-5.
The role of cyclosporine (CSA) alone or in combination with various chemotherapeutics in the development of renal toxicity was evaluated in rats. Administration of 20 mg/kg/day CSA for 4 weeks caused renal functional and structural changes similar to those reported in man. The combined administration of CSA and various chemotherapeutic drugs with a nephrotoxic potential, such as gentamicin (at therapeutic doses), amphothericin B and ketoconazole, which are frequently used in immunosuppressed patients, did not aggravate the CSA induced toxicity in the rat model. Gentamicin at toxic doses, however, increased CSA nephrotoxicity. Thus, the nephrotoxicity induced by CSA has a different pathogenetic mechanism.
在大鼠中评估了单独使用环孢素（CSA）或其与各种化疗药物联合使用在肾毒性发展中的作用。以20mg/kg/天的剂量给予CSA 4周，可引起与人类报告相似的肾功能和结构变化。CSA与各种具有肾毒性潜力的化疗药物联合使用，如常用于免疫抑制患者的庆大霉素（治疗剂量）、两性霉素B和酮康唑，在大鼠模型中并未加重CSA诱导的毒性。然而，毒性剂量的庆大霉素会增加CSA的肾毒性。因此，CSA诱导的肾毒性具有不同的发病机制。
