Ai Huisheng, Chao Nelson J, Rizzieri David A, Huang Xiaojun, Spitzer Thomas R, Wang Jianxiang, Guo Mei, Keating Armand, Krakow Elizabeth F, Blaise Didier, Ma Jun, Wu Depei, Reagan John, Gergis Usama, Duarte Rafael F, Chaudhary Preet M, Hu Kaixun, Yu Changlin, Sun Qiyun, Fuchs Ephraim, Cai Bo, Huang Yajing, Qiao Jianhui, Gottlieb David, Schultz Kirk R, Liu Mingyao, Chen Xiequn, Chen Wenming, Wang Jianmin, Zhang Xiaohui, Li Jianyong, Huang He, Sun Zimin, Li Fei, Yang Linhua, Zhang Liansheng, Li Lijuan, Liu Kaiyan, Jin Jie, Liu Qifa, Liu Daihong, Gao Chunji, Fan Chuanbo, Wei Li, Zhang Xi, Hu Liangding, Zhang Weijing, Tian Yuyang, Han Weidong, Zhu Jun, Xiao Zhijian, Zhou Daobin, Zhang Bolong, Jia Yongqian, Zhang Yongqing, Wu Xiaoxiong, Shen Xuliang, Lu Xuzhang, Zhan Xinrong, Sun Xiuli, Xiao Yi, Wang Jingbo, Shi Xiaodong, Zheng Bo, Chen Jieping, Ding Banghe, Wang Zhao, Zhou Fan, Zhang Mei, Zhang Yizhuo, Sun Jie, Xia Bing, Chen Baoan, Ma Liangming
Chinese PLA General Hospital, China.
Duke University, USA.
Heliyon. 2023 Mar 31;9(4):e14924. doi: 10.1016/j.heliyon.2023.e14924. eCollection 2023 Apr.
Recent studies have shown that microtransplant (MST) could improve outcome of patients with elderly acute myeloid leukemia (EAML). To further standardize the MST therapy and improve outcomes in EAML patients, based on analysis of the literature on MST, especially MST with EAML from January 1st, 2011 to November 30th, 2022, the International Microtransplant Interest Group provides recommendations and considerations for MST in the treatment of EAML. Four major issues related to MST for treating EAML were addressed: therapeutic principle of MST (1), candidates for MST (2), induction chemotherapy regimens (3), and post-remission therapy based on MST (4). Others included donor screening, infusion of donor cells, laboratory examinations, and complications of treatment.
近期研究表明，微移植（MST）可改善老年急性髓系白血病（EAML）患者的预后。为进一步规范MST治疗并改善EAML患者的预后，基于对MST文献的分析，特别是2011年1月1日至2022年11月30日期间EAML的MST文献，国际微移植兴趣小组提供了关于MST治疗EAML的建议和注意事项。讨论了与MST治疗EAML相关的四个主要问题：MST的治疗原则（1）、MST的候选者（2）、诱导化疗方案（3）以及基于MST的缓解后治疗（4）。其他包括供体筛查、供体细胞输注、实验室检查和治疗并发症。
