Huo Rongxiu, Huang Xinxiang, Yang Yanting, Yang Yang, Lin Jinying
Department of Rheumatology and Immunology, Guangxi Academy of Medical Sciences, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Front Pharmacol. 2023 Apr 6;14:1139460. doi: 10.3389/fphar.2023.1139460. eCollection 2023.
Interstitial lung disease (ILD) is a heterogeneous group of diseases characterized by lung injury caused by lung fibroblast proliferation, interstitial inflammation, and fibrosis. Different cell signal transduction pathways are activated in response to various proinflammatory or fibrotic cytokines, such as IL-6, and these cytokines are increased in different ILDs. The overexpressed cytokines and growth factors in ILD can activate TGF-β/Smad2/3/4, NF-κB, and JAK/STAT signal transduction pathways, promote the activation of immune cells, increase the release of pro-inflammatory and pro-fibrotic factors, differentiate fibroblasts into myofibroblasts, and promote the occurrence and development of ILD. This finding suggests the importance of signal transduction pathways in patients with ILD. Recent evidence suggests that resveratrol (RSV) attenuates excessive inflammation and pulmonary fibrosis by inhibiting the TGF-β/Smad2/3/4, NF-κB, and JAK/STAT signal transduction pathways and overactivation of immune cells. In this review, advances in lung protection and the underlying mechanisms of RSV are summarized, and the potential efficacy of RSV as a promising treatment option for ILD is highlighted.
间质性肺疾病（ILD）是一组异质性疾病，其特征是由肺成纤维细胞增殖、间质炎症和纤维化引起的肺损伤。针对各种促炎或促纤维化细胞因子（如IL-6），不同的细胞信号转导通路被激活，并且这些细胞因子在不同的ILD中会增加。ILD中过表达的细胞因子和生长因子可激活TGF-β/Smad2/3/4、NF-κB和JAK/STAT信号转导通路，促进免疫细胞的激活，增加促炎和促纤维化因子的释放，使成纤维细胞分化为肌成纤维细胞，并促进ILD的发生和发展。这一发现表明信号转导通路在ILD患者中的重要性。最近的证据表明，白藜芦醇（RSV）通过抑制TGF-β/Smad2/3/4、NF-κB和JAK/STAT信号转导通路以及免疫细胞的过度激活来减轻过度炎症和肺纤维化。在这篇综述中，总结了RSV在肺保护方面的进展及其潜在机制，并强调了RSV作为ILD一种有前景的治疗选择的潜在疗效。
