Safdari Amer, Sage Lucas, Singh Manmeet, Green Lauren
University of Illinois at Chicago College of Medicine, 1835 W Polk St, Chicago, IL 60612, USA.
Department of Radiology, University of Illinois Hospital and Health Sciences, 1740 W Taylor St 2600, Chicago, IL 60642, USA.
Radiol Case Rep. 2023 Apr 5;18(6):2081-2089. doi: 10.1016/j.radcr.2023.03.008. eCollection 2023 Jun.
Myofibroblastoma (MFB) of the breast is a rare benign neoplasm of the mammary stroma. Several morphologic variants have been described in the literature, which can create diagnostic challenges for pathologists, in particular the epithelioid variant of MFB, which can mimic invasive lobular carcinoma. We report a case of a 72-year-old female who presented for a painless breast lump and was later found to have 2 lesions on imaging, with 1 lesion corresponding to the palpable lump and the other lying in a different quadrant. Core-needle biopsies demonstrated ductal carcinoma in-situ at both lesional sites with what was originally felt to be an invasive lobular carcinoma at the lesional site which did not correspond to the palpable lump. After mastectomy, with more complete visualization microscopically of the lesional area originally felt to be an invasive lobular carcinoma, the final pathology was consistent with a MFB, predominantly epithelioid variant, in addition to ductal carcinoma in-situ and lobular carcinoma in-situ. In this paper we describe the imaging findings of an epithelioid MFB and how its nonspecific nature necessitates close communication between the radiologist and pathologist to make the correct diagnosis.
乳腺肌成纤维细胞瘤（MFB）是一种罕见的乳腺间质良性肿瘤。文献中描述了几种形态学变异型，这可能给病理学家带来诊断挑战，尤其是MFB的上皮样变异型，它可酷似浸润性小叶癌。我们报告1例72岁女性，因无痛性乳腺肿块就诊，影像学检查发现有2个病灶，其中1个病灶对应可触及的肿块，另一个位于不同象限。粗针活检显示两个病灶部位均为导管原位癌，最初认为其中一个病灶部位为浸润性小叶癌，该病灶并不对应可触及的肿块。乳房切除术后，通过显微镜更完整地观察最初认为是浸润性小叶癌的病灶区域，最终病理结果显示除导管原位癌和小叶原位癌外，还符合MFB，主要为上皮样变异型。在本文中，我们描述了上皮样MFB的影像学表现，以及其非特异性特征如何需要放射科医生和病理科医生密切沟通以做出正确诊断。
