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托吡酯诱发的小眼球水性错向综合征

Topiramate-Induced Aqueous Misdirection in a Nanophthalmic Eye.

作者信息

Hussain Ahsan, Snyder Kiersten, Paroya Shahnawaz, Mahesh Sankara

机构信息

Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, USA.

Ophthalmology, New York Medical College, Valhalla, USA.

出版信息

Cureus. 2023 Mar 22;15(3):e36529. doi: 10.7759/cureus.36529. eCollection 2023 Mar.

DOI:10.7759/cureus.36529
PMID:37090286
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10120882/
Abstract

A 51-year-old female was referred to the emergency department with a one-day history of severe right eye pain, blurry vision, and conjunctival injection. A review of past ocular history was notable for nanophthalmos and narrow angles with patent peripheral iridotomies. Anterior segment exam findings were consistent with aqueous misdirection and a review of medications indicated recent topiramate initiation for headaches and depression. The acute attack was initially controlled with medical management and plans for future surgical intervention were made. Although ocular screening prior to initiation of topiramate is not recommended, this case highlights the importance of pre-screening in a patient with a pre-existing condition such as nanophthalmos. Additionally, this case addresses the ocular side effects of anti-depressants and the emerging relationship between glaucoma and depression. Appropriately addressing these issues and coordinating care with behavioral health providers has the potential to prevent optic nerve damage and loss of vision.

摘要

一名51岁女性因右眼剧痛、视力模糊和结膜充血1天被转诊至急诊科。既往眼部病史显示有小眼球和窄房角,周边虹膜切开术通畅。前段检查结果与房水错流一致,药物审查表明近期开始使用托吡酯治疗头痛和抑郁症。急性发作最初通过药物治疗得到控制,并制定了未来手术干预计划。虽然不建议在开始使用托吡酯之前进行眼部筛查,但该病例突出了对患有小眼球等既往疾病的患者进行预筛查的重要性。此外,该病例还涉及抗抑郁药的眼部副作用以及青光眼与抑郁症之间新出现的关系。适当地解决这些问题并与行为健康提供者协调护理有可能预防视神经损伤和视力丧失。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e24/10120882/872becd23cf3/cureus-0015-00000036529-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e24/10120882/872becd23cf3/cureus-0015-00000036529-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e24/10120882/872becd23cf3/cureus-0015-00000036529-i01.jpg

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本文引用的文献

1
Depression in glaucoma patients: A review of the literature.青光眼患者的抑郁:文献综述。
Semin Ophthalmol. 2022 Jan 2;37(1):29-35. doi: 10.1080/08820538.2021.1903945. Epub 2021 Apr 6.
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The association between glaucoma and risk of depression: a nationwide population-based cohort study.青光眼与抑郁症风险之间的关联:一项基于全国人口的队列研究。
BMC Ophthalmol. 2018 Jun 22;18(1):146. doi: 10.1186/s12886-018-0811-5.
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The treatment of malignant glaucoma in nanophthalmos: a case report.小眼球恶性青光眼的治疗:一例报告
BMC Ophthalmol. 2018 Feb 23;18(1):54. doi: 10.1186/s12886-018-0714-5.
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Surgical management of malignant glaucoma: a retrospective analysis of fifty eight eyes.恶性青光眼的手术治疗:58 只眼的回顾性分析
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Anxiety and Depression are More Prevalent in Primary Angle Closure Glaucoma Than in Primary Open-Angle Glaucoma.原发性闭角型青光眼患者中焦虑和抑郁的患病率高于原发性开角型青光眼患者。
J Glaucoma. 2015 Jun-Jul;24(5):e57-63. doi: 10.1097/IJG.0000000000000025.
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Outcomes of different management options for malignant glaucoma: a retrospective study.不同恶性青光眼处理方法的结局:一项回顾性研究。
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Topiramate induced acute angle closure glaucoma.托吡酯诱发急性闭角型青光眼。
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9
Depression and quality of life in patients with glaucoma: a cross-sectional analysis using the Geriatric Depression Scale-15, assessment of function related to vision, and the Glaucoma Quality of Life-15.青光眼患者的抑郁与生活质量:一项使用老年抑郁量表-15、视力相关功能评估及青光眼生活质量-15的横断面分析
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Management of glaucoma in patients with nanophthalmos.小眼球患者青光眼的管理
Eye (Lond). 2008 Jun;22(6):838-43. doi: 10.1038/sj.eye.6702742. Epub 2007 Feb 9.