White W B, Schulman P, McCabe E J, Hager W D
Clin Pharmacol Ther. 1986 Jun;39(6):664-8. doi: 10.1038/clpt.1986.116.
We studied blood pressure (BP) and heart rate (HR) responses in 12 patients with hypertension who were receiving cetamolol, a cardioselective beta-blocker with intrinsic sympathomimetic activity. The BP and HR parameters were evaluated at rest (casual, office readings), with ambulatory BP monitoring, and after treadmill exercise testing. At a mean (+/- SD) dose of 46 +/- 21 mg/day, casual supine BP decreased by 10/12 mm Hg (P less than 0.05 for systolic; P less than 0.01 for diastolic) compared with placebo, while HR decreased 4 bpm. Cetamolol resulted in a significant reduction in the mean 24-hour systolic BP. The most striking reduction occurred in the BP at work (23 mm Hg), with almost no decrease in the BP during sleep. Ambulatory HR reductions occurred while the subjects were at work (9 bpm; P less than 0.05) but not while at home (awake) or during sleep. The mean duration of exercise was the same during cetamolol and placebo phases, but both HR and BP fell significantly at peak performance after cetamolol. These data suggest that cetamolol reduces BP without lowering HR at rest. During periods of increased adrenergic activity such as work and dynamic exercise, both HR and BP are reduced.
我们研究了12名正在服用塞他洛尔（一种具有内在拟交感活性的心脏选择性β受体阻滞剂）的高血压患者的血压（BP）和心率（HR）反应。通过静息状态（偶然的、诊室测量值）、动态血压监测以及跑步机运动试验来评估BP和HR参数。平均（±标准差）剂量为46±21毫克/天时，与安慰剂相比，静息仰卧位收缩压下降了10/12毫米汞柱（收缩压P<0.05；舒张压P<0.01），而心率下降了4次/分钟。塞他洛尔使24小时平均收缩压显著降低。最显著的血压下降发生在工作时（23毫米汞柱），睡眠期间血压几乎没有下降。动态心率在受试者工作时下降（9次/分钟；P<0.05），但在家中（清醒时）或睡眠期间没有下降。在塞他洛尔和安慰剂阶段，运动的平均持续时间相同，但在塞他洛尔作用下，运动高峰时HR和BP均显著下降。这些数据表明，塞他洛尔在静息时降低血压但不降低心率。在诸如工作和动态运动等肾上腺素能活动增加的时期，HR和BP均会降低。
