Sharma Anupriya, Sharma Ashish, Chauhan Rakesh, Chauhan Abhimanyu S, Parmar Monika, Thakur Sucheta
Dentistry, Dr. Radhakrishnan Government Medical College, Hamirpur, IND.
Neurology, All India Institute of Medical Sciences, Bilaspur, IND.
Cureus. 2023 Mar 22;15(3):e36530. doi: 10.7759/cureus.36530. eCollection 2023 Mar.
Background In this cohort study, the association between periodontal disease (PD) and recurrent vascular events was determined among the subjects with ischemic stroke/transient ischemic attack (TIA), and the extent and severity of periodontal disease were estimated among these subjects. Methods This prospective, longitudinal, hospital-based cohort study included 153 individuals who had a stroke or TIA. They were divided into two groups: high periodontal disease (HPD) (N=55, mean age: 59.40±12.21) and low periodontal disease (LPD) (N=98, mean age: 53.03±12.82). Clinical attachment loss (CAL) and probing pocket depth (PPD) were used to measure the severity of the periodontal disease. TOAST criteria were used to determine the ischemic stroke etiology, and the NIH Stroke Scale (NIHSS) was used to determine the ischemic stroke severity. A follow-up survey found that vascular incidents recurred. Results HPD individuals exhibited a higher median NIHSS (eight) than LPD patients (seven) in a subset of stroke population (N=23). Thirty-eight cardiovascular events occurred in the first three months after enrollment, including 23 strokes and seven TIAs, and five myocardial infarctions(MIs). There were three deaths from vascular causes. There was a non-significant association between PD and composite vascular events (HR 1.06, 95% CI, 1.03 to 1.09, p=0.71). Compound vascular events were not related to severe HPD (HR 1.31, 95 % CI 0.54 to 3.16, p=0.07). Conclusion In stroke/TIA patients, there is no link between high periodontal disease and recurrent vascular episodes. The proportions of stroke subtypes were not substantially different between HPD and LPD.
背景 在这项队列研究中，确定了缺血性中风/短暂性脑缺血发作（TIA）患者中牙周疾病（PD）与复发性血管事件之间的关联，并评估了这些患者牙周疾病的范围和严重程度。方法 这项基于医院的前瞻性纵向队列研究纳入了153例中风或TIA患者。他们被分为两组：高牙周疾病组（HPD）（N = 55，平均年龄：59.40±12.21）和低牙周疾病组（LPD）（N = 98，平均年龄：53.03±12.82）。采用临床附着丧失（CAL）和探诊深度（PPD）来衡量牙周疾病的严重程度。采用TOAST标准确定缺血性中风的病因，采用美国国立卫生研究院卒中量表（NIHSS）确定缺血性中风的严重程度。随访调查发现血管事件复发。结果 在一部分中风患者（N = 23）中，HPD个体的NIHSS中位数（8分）高于LPD患者（7分）。入组后的前三个月发生了38例心血管事件，包括23例中风、7例TIA和5例心肌梗死（MI）。有3例死于血管原因。PD与复合血管事件之间存在非显著关联（HR 1.06，95%CI，1.03至1.09，p = 0.71）。复合血管事件与严重HPD无关（HR 1.31，95%CI 0.54至3.16，p = 0.07）。结论 在中风/TIA患者中，高牙周疾病与复发性血管事件之间没有关联。HPD和LPD之间中风亚型的比例没有显著差异。
