Department of Emergency, China-Japan Friendship Hospital, Beijing, China.
China-Japan Friendship Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Front Immunol. 2023 Apr 5;14:1114103. doi: 10.3389/fimmu.2023.1114103. eCollection 2023.
Cytokine storms are an important mechanism of sepsis. TNF-α is an important cytokine. As a regulator of TNF superfamily receptors, RIPK1 not only serves as the basis of the scaffold structure in complex I to promote the activation of the NF-κB and MAPK pathways but also represents an important protein in complex II to promote programmed cell death. Ubiquitination of RIPK1 is an important regulatory function that determines the activation of cellular inflammatory pathways or the activation of death pathways. In this paper, we introduce the regulation of RIPK1, RIPK1 PANoptosome's role in Inflammatory and sepsis, and perspectives.
细胞因子风暴是脓毒症的一个重要机制。TNF-α 是一种重要的细胞因子。RIPK1 作为 TNF 超家族受体的调节剂，不仅作为复合物 I 中的支架结构基础，促进 NF-κB 和 MAPK 通路的激活，而且作为复合物 II 中的重要蛋白，促进程序性细胞死亡。RIPK1 的泛素化是决定细胞炎症途径激活或死亡途径激活的重要调节功能。本文介绍了 RIPK1 的调节、RIPK1 PANoptosome 在炎症和脓毒症中的作用以及研究展望。
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