Yu Yihan, Li Kanglu, Peng Yizhong, Wu Wei, Chen Fengxia, Shao Zengwu, Zhang Zhicai
Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China.
Front Oncol. 2023 Apr 5;13:1165380. doi: 10.3389/fonc.2023.1165380. eCollection 2023.
Cancer metastasis is a major cause of mortality from several tumors, including those of the breast, prostate, and the thyroid gland. Since bone tissue is one of the most common sites of metastasis, the treatment of bone metastases is crucial for the cure of cancer. Hence, disease models must be developed to understand the process of bone metastasis in order to devise therapies for it. Several translational models of different bone metastatic tumors have been developed, including animal models, cell line injection models, bone implant models, and patient-derived xenograft models. However, a compendium on different bone metastatic cancers is currently not available. Here, we have compiled several animal models derived from current experiments on bone metastasis, mostly involving breast and prostate cancer, to improve the development of preclinical models and promote the treatment of bone metastasis.
癌症转移是包括乳腺癌、前列腺癌和甲状腺癌在内的多种肿瘤致死的主要原因。由于骨组织是最常见的转移部位之一，因此骨转移的治疗对于癌症的治愈至关重要。因此，必须建立疾病模型来了解骨转移过程，以便为其设计治疗方法。目前已经开发了几种不同骨转移性肿瘤的转化模型，包括动物模型、细胞系注射模型、骨植入模型和患者来源的异种移植模型。然而，目前尚无关于不同骨转移性癌症的综述。在此，我们汇编了一些来自动前骨转移实验的动物模型，这些实验大多涉及乳腺癌和前列腺癌，以促进临床前模型的开发并推动骨转移的治疗。
