丝裂原活化蛋白激酶14相关长链非编码核糖核酸在多发性硬化症患者外周血中的异常表达
Abnormal expression of MAPK14-related lncRNAs in the peripheral blood of patients with multiple sclerosis.
作者信息
Ghafouri-Fard Soudeh, Gholipour Mahdi, Eslami Solat, Hussen Bashdar Mahmud, Taheri Mohammad, Samadian Mohammad, Omrani Mir Davood
机构信息
Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Noncoding RNA Res. 2023 Apr 6;8(3):335-339. doi: 10.1016/j.ncrna.2023.03.006. eCollection 2023 Sep.
INTRODUCTION
Contribution of MAPK14 in the pathogenesis of multiple sclerosis (MS) has been proposed by several studies. Long non-coding RNA (lncRNA) have been suggested to be functionally linked with Mitogen-activated protein kinase 14 (MAPK14).
METHODS
Expression levels of and its associated lncRNAs were measured in the circulation of MS patients compared with control subjects.
RESULTS
Expression levels of and were higher in total patients compared with controls (Expression ratio (95% CI) = 1.4 (1.04-1.89), P value = 0.015 and Expression ratio (95% CI) = 1.91 (1.43-2.6), P value = 0.0001, respectively). Conversely, was under-expressed in cases compared with controls (Expression ratio (95% CI) = 0.61 (0.41-0.8), P value = 0.0005). In spite of the observed abnormal expression levels of these lncRNAs in the circulation of MS patients, their expressions were not correlated with Expanded Disability Status Scale (EDSS) score, disease duration or age at disease onset.
CONCLUSION
To sum up, the current investigation shows dysregulation of MAPK14-related lncRNAs in MS patients.
引言
多项研究提出丝裂原活化蛋白激酶14（MAPK14）在多发性硬化症（MS）发病机制中的作用。长链非编码RNA（lncRNA）被认为与丝裂原活化蛋白激酶14（MAPK14）存在功能联系。
方法
与对照组相比，检测MS患者循环中[此处原文缺失具体基因名称]及其相关lncRNA的表达水平。
结果
与对照组相比，所有患者中[此处原文缺失具体基因名称]和[此处原文缺失具体基因名称]的表达水平更高（表达率（95%置信区间）分别为1.4（1.04 - 1.89），P值 = 0.015和表达率（95%置信区间） = 1.91（1.43 - 2.6），P值 = 0.0001）。相反，与对照组相比，[此处原文缺失具体基因名称]在病例中表达不足（表达率（95%置信区间） = 0.61（0.41 - 0.8），P值 = 0.0005）。尽管在MS患者循环中观察到这些lncRNA的表达水平异常，但其表达与扩展残疾状态量表（EDSS）评分、病程或发病年龄无关。
结论
综上所述，目前的研究表明MS患者中MAPK14相关lncRNA存在失调。
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