Veith Talitha, Bleicker Tobias, Eschbach-Bludau Monika, Brünink Sebastian, Mühlemann Barbara, Schneider Julia, Beheim-Schwarzbach Jörn, Rakotondranary S Jacques, Ratovonamana Yedidya R, Tsagnangara Cedric, Ernest Refaly, Randriantafika Faly, Sommer Simone, Stetter Nadine, Jones Terry C, Drosten Christian, Ganzhorn Jörg U, Corman Victor M
Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, Berlin 10117, Germany.
Institute of Virology, University Hospital, University of Bonn, Venusberg-Campus 1, Bonn 53127, Germany.
Virus Evol. 2023 Mar 27;9(1):vead024. doi: 10.1093/ve/vead024. eCollection 2023.
Adenoviruses (AdVs) are important human and animal pathogens and are frequently used as vectors for gene therapy and vaccine delivery. Surprisingly, there are only scant data regarding primate AdV origin and evolution, especially in the most basal primate hosts. We detect and sequence AdVs from faeces of two Madagascan lemur species. Complete genome sequence analyses define a new AdV species with a particularly large gene encoding a protein of unknown function in the early gene region 3. Unexpectedly, the new AdV species is not most similar to human or other simian AdVs but to bat adenovirus C. Genome characterisation shows signals of virus-host codivergence in non-structural genes, which show lower diversity than structural genes. Outside a lemur species mixing zone, recombination less frequently separates structural genes, as in human adenovirus C. The evolutionary history of lemur AdVs likely involves both a host switch and codivergence with the lemur hosts.
腺病毒（AdV）是重要的人类和动物病原体，常用于基因治疗和疫苗递送载体。令人惊讶的是，关于灵长类腺病毒起源和进化的数据非常少，尤其是在最原始的灵长类宿主中。我们从两种马达加斯加狐猴的粪便中检测并测序了腺病毒。完整基因组序列分析确定了一个新的腺病毒物种，其早期基因区域3中有一个特别大的基因，编码一种功能未知的蛋白质。出乎意料的是，新的腺病毒物种与人类或其他猿猴腺病毒的相似度并不高，而是与蝙蝠腺病毒C最为相似。基因组特征显示，非结构基因中存在病毒-宿主共分化的信号，其多样性低于结构基因。在狐猴物种混合区之外，重组较少像人类腺病毒C那样将结构基因分开。狐猴腺病毒的进化历史可能既涉及宿主转换，也涉及与狐猴宿主的共分化。
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