Laboratory of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan.
Laboratory of Veterinary Public Health, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Arch Virol. 2022 Mar;167(3):979-982. doi: 10.1007/s00705-021-05357-8. Epub 2022 Feb 3.
Here, we report a novel bat adenovirus strain isolated from apparently healthy bats of the species Rhinolophus cornutus in Japan. The genome of the isolate was 36,506 bp in length and encoded at least 33 proteins. Phylogenetic analysis of the DNA polymerase amino acid sequence, which provides one demarcation criterion for adenoviral species, indicated that the isolate belongs to the species Bat mastadenovirus C in the genus Mastadenovirus. Most of the encoded proteins shared high sequence similarity with those of known bat adenovirus C strains detected in different species of Rhinolophus, whereas the fiber protein and some E3- and E4-related proteins shared moderate similarity, and only the large E3 protein, which contains several host immune-suppression-related motifs, showed considerably lower similarity.
在这里，我们报告了一种从日本角鼻蝠属的明显健康蝙蝠中分离出来的新型蝙蝠腺病毒株。该分离株的基因组长度为 36506 个碱基对，编码至少 33 种蛋白质。聚合酶氨基酸序列的系统发育分析为腺病毒种的一个划分标准，表明该分离株属于 Mastadenovirus 属的蝙蝠腺病毒 C 种。大多数编码蛋白与在不同种类的角鼻蝠中检测到的已知蝙蝠腺病毒 C 株具有很高的序列相似性，而纤维蛋白和一些 E3 和 E4 相关蛋白具有中等相似性，只有包含几个宿主免疫抑制相关基序的大 E3 蛋白显示出相当低的相似性。
