大体积白细胞分离术对高白细胞白血病患者血红蛋白、血小板和凝血的影响。

The effects of large-volume leukapheresis on hemoglobin, platelet and coagulation in patients with hyperleukocytic leukemia.

机构信息

Department of Hematology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

Department of Stomatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

出版信息

Clin Hemorheol Microcirc. 2023;84(3):275-281. doi: 10.3233/CH-231737.

DOI:10.3233/CH-231737

PMID:37092218

Abstract

INTRODUCTION

This study retrospectively analyzed a total of 86 leukapheresis treatments in 55 patients with hyperleukocytic leukemia (HLL).

METHODS

In the leukapheresis treatments, the monitoring collection (MNC) program in COBE spectra continuous flow centrifuge (CFC) for blood component separator was used.

RESULTS

In this study, the white blood cell (WBC) suspension volume collected in leukapheresis treatment were 870.72±208.40 mL, and significantly larger than that reported in previous study. Compared with before leukapheresis, there were no difference in patient with HLL on the peripheral blood platelet (PLT) count and hemoglobin (HGB) levels. The index plasma fibrinogen (FIB) concentration was slightly reduced by leukapheresis, however, it did not affect a lot the maintenance of normal hemostatic function in patients with HLL.

DISCUSSION

Our data provided evidences that large-volume leukapheresis had no obvious effects on HGB level and coagulation functions in patient with HLL. So large-volume leukapheresis by CFC could be widely used in clinic.

摘要

简介

本研究回顾性分析了 55 例高白细胞白血病（HLL）患者共 86 次白细胞单采治疗。

方法

白细胞单采治疗中使用了 COBE spectra 连续流离心机制备血液成分分离机的监测采集（MNC）程序。

结果

本研究中，白细胞单采治疗中采集的白细胞悬液体积为 870.72±208.40ml，明显大于以往研究报道的体积。与白细胞单采治疗前相比，HLL 患者的外周血血小板（PLT）计数和血红蛋白（HGB）水平无差异。白细胞单采治疗后，纤维蛋白原（FIB）浓度略有降低，但对 HLL 患者的正常止血功能维持影响不大。