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青少年特发性脊柱侧凸后路融合术后延迟活动的影响:单机构研究。

Effects of delayed ambulation following posterior spinal fusion for adolescent idiopathic scoliosis: a single institutional study.

机构信息

Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.

Department of Orthopedics, Yale University School of Medicine, New Haven, CT, USA.

出版信息

Spine Deform. 2023 Sep;11(5):1127-1136. doi: 10.1007/s43390-023-00693-y. Epub 2023 Apr 24.

Abstract

OBJECTIVE

Mobilizing out of bed and ambulation are key components of recovery following posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS). However, there remains a paucity of studies identifying risk factors associated with delayed ambulation and its impact on postoperative outcomes. The aim of this study was to investigate patient- and surgical-level risk factors associated with delayed ambulation and the ramifications of delayed ambulation on healthcare utilization for patients undergoing PSF for AIS.

METHODS

The medical records of 129 adolescent (10-18 years) patients diagnosed with AIS undergoing posterior spinal fusion at a major academic institution between 2013 and 2020 were reviewed. Patients were categorized based on days from surgery to ambulation: early (≤ 1 day), intermediate (2 days), or late (≥ 3 days). Patient demographics, comorbidities, spinal deformity characteristics, intraoperative variables, postoperative complications, LOS, and unplanned readmissions were assessed. The odds ratios for risk-adjusted delayed ambulation and extended LOS were determined via multivariate stepwise logistic regressions.

RESULTS

One Hundred and Twenty Nine patients were included in this study, of which 10.8% (n = 14) were classified as Early ambulators, 41.9% (n = 54) Intermediate ambulators, and 47.3% (n = 61) were Late ambulators. Late ambulators were significantly younger than early and intermediate ambulators (Early: 15.7 ± 1.9 years vs. Intermediate: 14.8 ± 1.7 years vs. Late: 14.1 ± 1.9 years, p = 0.010). The primary and secondary spinal curves were significantly worse among Late ambulators (p < 0.001 and p = 0.002 respectively). Fusion levels (p < 0.01), EBL (p = 0.014), and the rate of RBC transfusions (p < 0.001) increased as time to ambulation increased. Transition time from IV to oral pain medications (Early: 1.6 ± 0.8 days vs. Intermediate: 2.2 ± 0.6 days vs. Late: 2.4 ± 0.6 days, p < 0.001) and total hospital length of stay (Early: 3.9 ± 1.4 days vs. Intermediate: 4.7 ± 0.9 days vs. Late: 5.1 ± 1.2 days, p < 0.001) were longer in Late ambulators. On multivariate analysis, significant predictors of delayed ambulation included primary curve degree ≥ 70° [aOR: 5.67 (1.29‒31.97), p = 0.030] and procedure time [aOR: 1.66 (1.1‒2.59), p = 0.019].

CONCLUSIONS

Our study suggests that there may be patient- and surgical-level factors that are independently associated with late ambulation following PSF for AIS, including extent of major curve and length of operative time. Additionally, delayed ambulation has implications to length of hospital stay and postoperative complications.

摘要

目的

对于青少年特发性脊柱侧凸(AIS)患者进行后路脊柱融合术后,下床活动和行走是康复的关键组成部分。然而,目前仍然缺乏研究来确定与延迟行走相关的风险因素及其对术后结果的影响。本研究旨在调查与延迟行走相关的患者和手术水平的风险因素,以及延迟行走对接受 AIS 后路脊柱融合术患者医疗保健利用的影响。

方法

回顾了 2013 年至 2020 年间在一家主要学术机构接受后路脊柱融合术的 129 名青少年(10-18 岁)患者的病历。根据术后至行走的天数将患者分为:早期(≤1 天)、中期(2 天)或晚期(≥3 天)。评估了患者的人口统计学、合并症、脊柱畸形特征、术中变量、术后并发症、住院时间(LOS)和非计划性再入院情况。通过多变量逐步逻辑回归确定风险调整后延迟行走和延长 LOS 的优势比。

结果

本研究共纳入 129 名患者,其中 10.8%(n=14)为早期行走者,41.9%(n=54)为中期行走者,47.3%(n=61)为晚期行走者。晚期行走者明显比早期和中期行走者年轻(早期:15.7±1.9 岁;中期:14.8±1.7 岁;晚期:14.1±1.9 岁,p=0.010)。晚期行走者的主要和次要脊柱曲线明显较差(p<0.001 和 p=0.002)。融合节段(p<0.01)、EBL(p=0.014)和红细胞输血率(p<0.001)随行走时间的增加而增加。从静脉到口服止痛药的过渡时间(早期:1.6±0.8 天;中期:2.2±0.6 天;晚期:2.4±0.6 天,p<0.001)和总住院时间(早期:3.9±1.4 天;中期:4.7±0.9 天;晚期:5.1±1.2 天,p<0.001)在晚期行走者中更长。多变量分析显示,延迟行走的显著预测因素包括主要曲线度数≥70°[优势比:5.67(1.29-31.97),p=0.030]和手术时间[优势比:1.66(1.1-2.59),p=0.019]。

结论

我们的研究表明,可能存在与 AIS 后路脊柱融合术后延迟行走相关的患者和手术水平的因素,包括主要曲线的程度和手术时间。此外,延迟行走对住院时间和术后并发症有影响。

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