Nahata M C
Drug Intell Clin Pharm. 1986 May;20(5):367-9. doi: 10.1177/106002808602000506.
The purpose of this article is to emphasize the importance of infusion method on therapeutic drug monitoring in pediatric patients. Although effective serum concentrations are anticipated after intravenous infusion of drugs, studies with chloramphenicol and tobramycin have shown that the infusion method can have a profound influence on peak serum concentration and time to achieve peak concentration during therapy. Factors including infusion rate, injection site, volume of drug and fluid to be infused in the tubing, and type of infusion system should be considered for accurate drug delivery. Specific guidelines for drug infusions should be available at each institution. Since serum concentration predictions are based on the dose infused and infusion time, meaningful therapeutic monitoring data can be generated only with the understanding of the influence of infusion method on serum concentration-time profile of drugs.
本文的目的是强调输注方法在儿科患者治疗药物监测中的重要性。尽管静脉输注药物后预期会达到有效的血清浓度，但氯霉素和妥布霉素的研究表明，输注方法可对治疗期间的血清峰值浓度及达到峰值浓度的时间产生深远影响。为实现准确给药，应考虑包括输注速率、注射部位、输液管中要输注的药物和液体体积以及输注系统类型等因素。每个机构都应有具体的药物输注指南。由于血清浓度预测基于输注剂量和输注时间，因此只有了解输注方法对药物血清浓度-时间曲线的影响，才能生成有意义的治疗监测数据。
