Nahata M C, Powell D A, Glazer J P, Hilty M D
J Pediatr. 1981 Sep;99(3):463-6. doi: 10.1016/s0022-3476(81)80351-4.
The delivery rates of chloramphenicol succinate from a standard pediatric intravenous infusion set were studied in vitro at varying flow rates and injection sites of the infusion set. The pharmacokinetic properties of CAPS and chloramphenicol were then studied in 15 children given intravenous injections of CAPS via the infusion set at the flashball and Buretrol sites in a crossover fashion on successive days. In vitro, the actual times required for 95% delivery of CAPS from the infusion set were two- to fourfold longer than the predicted infusion times at flow rates of 5, 15, and 29 ml/min and at all three available injection sites. In vivo, flashball injections vs Buretrol injections resulted in significantly higher mean peak serum concentrations of CAPS and CAP, with peaks occurring significantly sooner after the beginning of the intravenous infusion. These results suggest a need for considering characteristics of CAPS infusion when monitoring and interpreting serum concentration values.
在不同流速和输液器注射部位的条件下，对标准儿科静脉输液器中琥珀氯霉素的释放率进行了体外研究。然后，对15名儿童进行了研究，这些儿童连续几天以交叉方式通过输液器在闪球（flashball）和布勒特罗尔（Buretrol）部位静脉注射琥珀氯霉素，以此研究琥珀氯霉素（CAPS）和氯霉素的药代动力学特性。在体外，在流速为5、15和29毫升/分钟以及所有三个可用注射部位时，从输液器中释放95%琥珀氯霉素所需的实际时间比预测的输液时间长两到四倍。在体内，闪球注射与布勒特罗尔注射相比，琥珀氯霉素和氯霉素的平均血清峰值浓度显著更高，且在静脉输液开始后峰值出现得明显更早。这些结果表明，在监测和解释血清浓度值时，需要考虑琥珀氯霉素输液的特点。
