Department of Neurological Surgery, University of Washington, Seattle, Washington, USA.
Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, Washington, USA.
J Gerontol A Biol Sci Med Sci. 2023 Aug 2;78(8):1309-1319. doi: 10.1093/gerona/glad107.
Changes in the brain and spinal cord microvasculature during normal aging contribute to the "sensitive" nature of aged central nervous system tissue to ischemic insults. In this review, we will examine alterations in the central nervous system microvasculature during normal aging, which we define as aging without a dominant pathology such as neurodegenerative processes, vascular injury or disease, or trauma. We will also discuss newer technologies to improve the study of central nervous system microvascular structure and function. Microvasculature within the brain and spinal cord will be discussed separately as anatomy and physiology differ between these compartments. Lastly, we will identify critical areas for future studies as well as key unanswered questions.
在正常衰老过程中，大脑和脊髓微血管的变化导致中枢神经系统组织对缺血性损伤变得“敏感”。在这篇综述中，我们将研究正常衰老过程中中枢神经系统微血管的变化，我们将其定义为没有主导性病理（如神经退行性过程、血管损伤或疾病或创伤）的衰老。我们还将讨论改善中枢神经系统微血管结构和功能研究的新技术。由于这些隔室的解剖和生理学不同，因此将分别讨论脑内和脊髓内的微血管。最后，我们将确定未来研究的关键领域以及未解决的关键问题。
