Zhu Sipin, Chen Min, Ying Yibo, Wu Qiuji, Huang Zhiyang, Ni Wenfei, Wang Xiangyang, Xu Huazi, Bennett Samuel, Xiao Jian, Xu Jiake
Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Molecular Pharmacology Research Centre, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Bone Res. 2022 Mar 16;10(1):30. doi: 10.1038/s41413-022-00203-2.
Vascular regeneration is a challenging topic in tissue repair. As one of the important components of the neurovascular unit (NVU), pericytes play an essential role in the maintenance of the vascular network of the spinal cord. To date, subtypes of pericytes have been identified by various markers, namely the PDGFR-β, Desmin, CD146, and NG2, each of which is involved with spinal cord injury (SCI) repair. In addition, pericytes may act as a stem cell source that is important for bone development and regeneration, whilst specific subtypes of pericyte could facilitate bone fracture and defect repair. One of the major challenges of pericyte biology is to determine the specific markers that would clearly distinguish the different subtypes of pericytes, and to develop efficient approaches to isolate and propagate pericytes. In this review, we discuss the biology and roles of pericytes, their markers for identification, and cell differentiation capacity with a focus on the potential application in the treatment of SCI and bone diseases in orthopedics.
血管再生是组织修复中一个具有挑战性的课题。作为神经血管单元（NVU）的重要组成部分之一，周细胞在维持脊髓血管网络方面发挥着至关重要的作用。迄今为止，已通过各种标志物鉴定出周细胞的亚型，即血小板衍生生长因子受体β（PDGFR-β）、结蛋白、CD146和NG2，它们各自都与脊髓损伤（SCI）修复有关。此外，周细胞可能作为对骨骼发育和再生很重要的干细胞来源，而特定亚型的周细胞可促进骨折和骨缺损修复。周细胞生物学的主要挑战之一是确定能够清晰区分不同亚型周细胞的特异性标志物，并开发分离和扩增周细胞的有效方法。在这篇综述中，我们讨论周细胞的生物学特性和作用、其鉴定标志物以及细胞分化能力，重点关注其在治疗脊髓损伤和骨科骨疾病中的潜在应用。
