Goheen S C, O'Rourke L, Larkin E C
Environ Res. 1986 Jun;40(1):47-57. doi: 10.1016/s0013-9351(86)80080-9.
Two experiments were carried out to determine whether ozone causes significant oxidation of pulmonary polyunsaturated fatty acids in vivo. These involved ad libitum and pair-feeding. In the first experiment, rats were fed fat-free diets and exposed to ozone for 0, 1, 2, and 4 weeks. Lung and liver fatty acids were analyzed to determine if the rats exposed to ozone lost essential fatty acids more rapidly than those exposed to filtered air. In the second experiment, rats were divided into four groups. Two of these groups were fed fat-free diets, and two were fed diets containing essential fatty acids. Rats from the two diet groups (one of each type) were exposed to ozone, while the remaining two groups were exposed to filtered air. In the second experiment, rats were pair-fed. The amounts of lung and liver fatty acids were relatively uninfluenced by breathing ozone. Results from these experiments demonstrate that in the lung, the polyunsaturated fatty acids, linoleic and arachidonic acids, appear to be oxidized by filtered air and ozone at essentially the same rate.
进行了两项实验以确定臭氧是否会在体内导致肺部多不饱和脂肪酸的显著氧化。这些实验包括随意进食和配对喂养。在第一个实验中，给大鼠喂食无脂饮食，并使其暴露于臭氧中0、1、2和4周。分析肺和肝脏脂肪酸，以确定暴露于臭氧的大鼠是否比暴露于过滤空气的大鼠更快地损失必需脂肪酸。在第二个实验中，将大鼠分为四组。其中两组喂食无脂饮食，两组喂食含有必需脂肪酸的饮食。来自两种饮食组（每种类型各一组）的大鼠暴露于臭氧中，而其余两组暴露于过滤空气中。在第二个实验中，大鼠进行配对喂养。呼吸臭氧对肺和肝脏脂肪酸的含量影响相对较小。这些实验的结果表明，在肺部，多不饱和脂肪酸亚油酸和花生四烯酸被过滤空气和臭氧氧化的速率基本相同。
