Tyler W S, Tyler N K, Last J A, Barstow T J, Magliano D J, Hinds D M
Department of Anatomy, School of Veterinary Medicine, University of California, Davis 95616.
Toxicology. 1987 Oct 12;46(1):1-20. doi: 10.1016/0300-483x(87)90133-8.
Minor differences in lung growth and development during childhood have been considered as a potential cause of rapid decline in pulmonary function in adulthood. Inhalation of ozone commonly causes changes in both body weight and lung volumes, which complicates interpretation of any changes in lung growth. The effects of ozone on lung growth were studied in rats which were pair fed. This technique permitted comparison of ozone-exposed and filtered-air control rats of the same body weight and body size as well as age and sex. Exposure was to filtered air or to 0.64 or 0.96 ppm ozone (UV standard) 8 h/night for 42 nights. A second control group was fed ad libitum and exposed to only filtered air. Half the rats were studied at the end of the 42-night exposures, the rest after a 42-day post-exposure period during which all rats were fed ab libitum and breathed filtered air. Rats examined at the end of the exposure period had larger saline and fixed lung volumes. These larger lungs had greater volumes of parenchyma, alveoli and respiratory bronchioles. Some of these changes persisted throughout a 42-day post-exposure period. Ozone inhalation by young rats alters lung growth and development in ways likely to be detrimental and those changes persist after ozone inhalation stops.
儿童期肺生长和发育的微小差异被认为是成年后肺功能迅速下降的一个潜在原因。吸入臭氧通常会导致体重和肺容积的变化，这使得对肺生长的任何变化的解释变得复杂。在成对喂养的大鼠中研究了臭氧对肺生长的影响。这项技术允许比较体重、体型以及年龄和性别相同的臭氧暴露大鼠和过滤空气对照大鼠。暴露于过滤空气或0.64或0.96 ppm臭氧（紫外线标准），每晚8小时，共42晚。第二个对照组自由进食并仅暴露于过滤空气中。一半的大鼠在42晚暴露结束时进行研究，其余的在42天的暴露后期间结束后进行研究，在此期间所有大鼠自由进食并呼吸过滤空气。在暴露期结束时检查的大鼠有更大的生理盐水和固定肺容积。这些更大的肺有更大体积的实质、肺泡和呼吸性细支气管。其中一些变化在42天的暴露后期间持续存在。幼鼠吸入臭氧会以可能有害的方式改变肺的生长和发育，并且这些变化在停止吸入臭氧后仍然存在。
