原发性开角型青光眼患者系统白细胞介素-6 转导信号的评估。
Evaluation of systemic IL-6 trans-signalling in patients with primary open-angle glaucoma.
机构信息
Research Center for Pre-Clinical and Clinical Medicine, National Research and Innovation Agency Republic of Indonesia, Cibinong, Indonesia; Laboratory of Developmental Disorders and Toxicology, Center for Promotion of International Education and Research, Kyushu University, Fukuoka, Japan.
Department of Nutrition, Faculty of Health Sciences, Brawijaya University, Malang, Indonesia.
出版信息
J Fr Ophtalmol. 2023 Jun;46(6):622-629. doi: 10.1016/j.jfo.2022.11.022. Epub 2023 Apr 22.
PURPOSE
To evaluate systemic trans-signalling of interleukin (IL)-6 in patients with primary open-angle glaucoma (POAG).
METHODS
Fifty-one POAG patients and 47 matched healthy controls were enrolled. Serum concentrations of IL-6, sIL-6R, and sgp130 were quantified.
RESULTS
Serum levels of IL-6, sIL-6R, and IL-6/sIL-6R ratios in the POAG group were significantly higher than those in control group, while only the sgp130/sIL-6R/IL-6 ratio was decreased. Among POAG subjects, advanced-stage patients exhibited significantly higher intraocular pressure (IOP), serum IL-6 and sgp130 levels, and IL-6/sIL-6R ratio than those in the early to moderate stage. The ROC curve analysis revealed that the IL-6 level and IL-6/sIL-6R ratio performed better than other parameters in diagnosing POAG and discriminating POAG severity. Serum IL-6 level was moderately correlated with IOP and C/D ratio, while a weak correlation was observed between sIL-6R levels with C/D ratio. IL-6 and sIL-6R levels were correlated with each other in POAG patients but not in healthy controls.
CONCLUSION
Overstimulation of systemic IL-6 trans-signalling has been implicated in POAG.
目的
评估白细胞介素（IL）-6 在原发性开角型青光眼（POAG）患者中的系统反式信号转导。
方法
纳入 51 例 POAG 患者和 47 名匹配的健康对照者。定量检测血清 IL-6、sIL-6R 和 sgp130 的浓度。
结果
POAG 组血清 IL-6、sIL-6R 和 IL-6/sIL-6R 比值明显高于对照组，而 sgp130/sIL-6R/IL-6 比值则降低。在 POAG 患者中，晚期患者的眼内压（IOP）、血清 IL-6 和 sgp130 水平以及 IL-6/sIL-6R 比值显著高于早期至中期患者。ROC 曲线分析显示，IL-6 水平和 IL-6/sIL-6R 比值在诊断 POAG 和区分 POAG 严重程度方面优于其他参数。血清 IL-6 水平与 IOP 和 C/D 比值中度相关，而 sIL-6R 水平与 C/D 比值则呈弱相关。POAG 患者中 IL-6 和 sIL-6R 水平相互关联，但在健康对照组中则没有。
结论
全身 IL-6 反式信号转导过度刺激可能与 POAG 有关。
Zotero 插件