SARS-CoV-2 变体和突变模式：与地塞米松时代危重症 COVID-19 患者呼吸机相关性肺炎风险的关系。
SARS-CoV-2 variants and mutational patterns: relationship with risk of ventilator-associated pneumonia in critically ill COVID-19 patients in the era of dexamethasone.
机构信息
Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), 51, Av de Lattre de Tassigny, 94000, Créteil Cedex, France.
Groupe de Recherche Clinique CARMAS, Université Paris-Est-Créteil (UPEC), Créteil, France.
出版信息
Sci Rep. 2023 Apr 24;13(1):6658. doi: 10.1038/s41598-023-33639-5.
We aimed to explore the relationships between specific viral mutations/mutational patterns and ventilator-associated pneumonia (VAP) occurrence in COVID-19 patients admitted in intensive care units between October 1, 2020, and May 30, 2021. Full-length SARS-CoV-2 genomes were sequenced by means of next-generation sequencing. In this prospective multicentre cohort study, 259 patients were included. 222 patients (47%) had been infected with pre-existing ancestral variants, 116 (45%) with variant α, and 21 (8%) with other variants. 153 patients (59%) developed at least one VAP. There was no significant relationship between VAP occurrence and a specific SARS CoV-2 lineage/sublineage or mutational pattern.
我们旨在探索 2020 年 10 月 1 日至 2021 年 5 月 30 日期间入住重症监护病房的 COVID-19 患者中特定病毒突变/突变模式与呼吸机相关性肺炎（VAP）发生之间的关系。通过下一代测序对全长 SARS-CoV-2 基因组进行测序。在这项前瞻性多中心队列研究中，共纳入 259 例患者。222 例（47%）患者感染了先前存在的祖先进化变体，116 例（45%）感染了变体 α，21 例（8%）感染了其他变体。153 例（59%）患者至少发生了一次 VAP。VAP 的发生与特定的 SARS-CoV-2 谱系/亚谱系或突变模式之间没有显著关系。
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