癌症中的 RNA 修饰。
RNA modifications in cancer.
机构信息
NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 410078, Changsha, Hunan, China.
Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China.
出版信息
Br J Cancer. 2023 Aug;129(2):204-221. doi: 10.1038/s41416-023-02275-1. Epub 2023 Apr 24.
Currently, more than 170 modifications have been identified on RNA. Among these RNA modifications, various methylations account for two-thirds of total cases and exist on almost all RNAs. Roles of RNA modifications in cancer are garnering increasing interest. The research on mA RNA methylation in cancer is in full swing at present. However, there are still many other popular RNA modifications involved in the regulation of gene expression post-transcriptionally besides mA RNA methylation. In this review, we focus on several important RNA modifications including mA, mC, mG, 2'-O-Me, Ψ and A-to-I editing in cancer, which will provide a new perspective on tumourigenesis by peeking into the complex regulatory network of epigenetic RNA modifications, transcript processing, and protein translation.
目前，已经在 RNA 上鉴定出超过 170 种修饰。在这些 RNA 修饰中，各种甲基化占总案例的三分之二，几乎存在于所有 RNA 上。RNA 修饰在癌症中的作用引起了越来越多的关注。目前，关于 mA RNA 甲基化在癌症中的研究正在全面展开。然而，除了 mA RNA 甲基化之外，还有许多其他常见的 RNA 修饰参与了转录后基因表达的调控。在这篇综述中，我们重点介绍了几种重要的 RNA 修饰，包括 mA、mC、mG、2'-O-Me、Ψ和 A-to-I 编辑在癌症中的作用，这将通过深入研究表观遗传 RNA 修饰、转录加工和蛋白质翻译的复杂调控网络，为肿瘤发生提供一个新的视角。
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