Ingenito A, Catelani C, Mercaldo A, d'Agata A, Cappelli G, Andreoli F
Eur Surg Res. 1986;18(2):129-32. doi: 10.1159/000128515.
We have developed a personal procedure for the radioimmunoassay of gastrin (lower detection limit 3 pg/ml). Using 5-fold concentrated lyophilized salivary samples, we are able to detect the basal content of gastrin immunoreactivity in saliva of normal fasting people (mean +/- SD: 1.38 +/- 0.61 pg/ml) compared to plasma gastrin (mean +/- SD: 28.88 +/- 11.00 pg/ml). We found that after meal stimulus, the value of salivary as well as plasma gastrin concentration increased (the correlation coefficient r among salivary and plasma gastrin being 0.899; p less than 0.001). We believe that gastrin appears in a very low concentration in saliva and that it is not produced by the gland, but derives probably from the serum clearance.
我们已经开发出一种用于胃泌素放射免疫测定的个人程序（检测下限为3 pg/ml）。使用5倍浓缩的冻干唾液样本，我们能够检测正常空腹人群唾液中胃泌素免疫反应性的基础含量（平均值±标准差：1.38±0.61 pg/ml），并与血浆胃泌素（平均值±标准差：28.88±11.00 pg/ml）进行比较。我们发现，餐后刺激后，唾液和血浆胃泌素浓度值均升高（唾液和血浆胃泌素之间的相关系数r为0.899；p<0.001）。我们认为胃泌素在唾液中的浓度非常低，它不是由腺体产生的，可能来源于血清清除。
