Liu Ruimin, Han Yinying, Huang Chenglong, Hou Mengqian, Cheng Rui, Wang Shujin, Li Xi, Tian Jie
Department of Cardiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400032, PR China.
Biology Science Institutes, Chongqing Medical University, Chongqing 400032, PR China.
iScience. 2023 Mar 24;26(4):106495. doi: 10.1016/j.isci.2023.106495. eCollection 2023 Apr 21.
Chemerin, an adipocyte-secreted protein, has been recently suggested to be linked to metabolic syndrome and cardiac function in obese and diabetes mellitus. This study aimed to investigate the potential roles of adipokine chemerin on high fat-induced cardiac dysfunction. Chemerin () knockout mice, which were fed with either a normal diet or a high-fat diet for 20 weeks, were employed to observe whether adipokine chemerin affected lipid metabolism, inflammation, and cardiac function. Firstly, we found normal metabolic substrate inflexibility and cardiac function in mice with a normal diet. Notably, in a high-fat diet, mice showed lipotoxicity, insulin resistance, and inflammation, thus causing metabolic substrate inflexibility and cardiac dysfunction. Furthermore, by using model of lipid-overload cardiomyocytes, we found chemerin supplementation reversed the lipid-induced abnormalities above. Herein, in the presence of obesity, adipocyte-derived chemerin might function as an endogenous cardioprotective factor against obese-related cardiomyopathy.
凯莫瑞蛋白是一种脂肪细胞分泌的蛋白质，最近有研究表明它与肥胖和糖尿病患者的代谢综合征及心脏功能有关。本研究旨在探讨脂肪因子凯莫瑞蛋白在高脂诱导的心脏功能障碍中的潜在作用。将喂食正常饮食或高脂饮食20周的凯莫瑞蛋白（）基因敲除小鼠用于观察脂肪因子凯莫瑞蛋白是否会影响脂质代谢、炎症反应和心脏功能。首先，我们发现喂食正常饮食的小鼠具有正常的代谢底物适应性和心脏功能。值得注意的是，在高脂饮食中，小鼠表现出脂毒性、胰岛素抵抗和炎症反应，从而导致代谢底物适应性降低和心脏功能障碍。此外，通过使用脂质过载心肌细胞模型，我们发现补充凯莫瑞蛋白可逆转上述脂质诱导的异常情况。在此，在肥胖存在的情况下，脂肪细胞衍生的凯莫瑞蛋白可能作为一种内源性心脏保护因子，对抗肥胖相关的心肌病。
