Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Department of Neuroscience, Catholic University of Sacred Heart, Rome, Italy.
Alzheimers Dement. 2023 Jul;19(7):3186-3202. doi: 10.1002/alz.13105. Epub 2023 Apr 24.
Operationalized research criteria for mild cognitive impairment with Lewy bodies (MCI-LB) were published in 2020. The aim of this systematic review and meta-analysis was to review the evidence for the diagnostic clinical features and biomarkers in MCI-LB set out in the criteria.
MEDLINE, PubMed, and Embase were searched on 9/28/22 for relevant articles. Articles were included if they presented original data reporting the rates of diagnostic features in MCI-LB.
Fifty-seven articles were included. The meta-analysis supported the inclusion of the current clinical features in the diagnostic criteria. Evidence for striatal dopaminergic imaging and meta-iodobenzylguanidine cardiac scintigraphy, though limited, supports their inclusion. Quantitative electroencephalogram (EEG) and fluorodeoxyglucose positron emission tomography (PET) show promise as diagnostic biomarkers.
The available evidence largely supports the current diagnostic criteria for MCI-LB. Further evidence will help refine the diagnostic criteria and understand how best to apply them in clinical practice and research.
A meta-analysis of the diagnostic features of MCI-LB was carried out. The four core clinical features were more common in MCI-LB than MCI-AD/stable MCI. Neuropsychiatric and autonomic features were also more common in MCI-LB. More evidence is needed for the proposed biomarkers. FDG-PET and quantitative EEG show promise as diagnostic biomarkers in MCI-LB.
2020 年发表了路易体轻度认知障碍（MCI-LB）的操作性研究标准。本系统评价和荟萃分析的目的是回顾标准中列出的 MCI-LB 的诊断临床特征和生物标志物的证据。
于 2022 年 9 月 28 日在 MEDLINE、PubMed 和 Embase 上搜索相关文章。如果文章报告了 MCI-LB 中诊断特征的发生率的原始数据，则将其纳入。
共纳入 57 篇文章。荟萃分析支持将当前临床特征纳入诊断标准。尽管有限，但支持纳入纹状体多巴胺能成像和 meta-碘苄胍心脏闪烁显像的证据。定量脑电图（EEG）和氟脱氧葡萄糖正电子发射断层扫描（PET）显示出作为诊断生物标志物的潜力。
现有证据在很大程度上支持当前的 MCI-LB 诊断标准。进一步的证据将有助于完善诊断标准，并了解如何在临床实践和研究中最好地应用它们。
对 MCI-LB 的诊断特征进行了荟萃分析。与 MCI-AD/稳定 MCI 相比，MCI-LB 中更常见四个核心临床特征。神经精神和自主神经特征在 MCI-LB 中也更为常见。对于提议的生物标志物，需要更多的证据。FDG-PET 和定量 EEG 显示出作为 MCI-LB 诊断生物标志物的潜力。
