超选择性、超清洁的一维旋转框架 Overhauser 效应光谱学。

Ultra-selective, ultra-clean 1D rotating-frame Overhauser effect spectroscopy.

机构信息

Department of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.

Johnson Matthey, Johnson Matthey Technology Centre, Sonning Common, Blounts Court Road, Reading RG4 9NH, UK.

出版信息

Chem Commun (Camb). 2023 May 11;59(39):5854-5857. doi: 10.1039/d3cc00550j.

DOI:10.1039/d3cc00550j

PMID:37096458

Abstract

An ultra-selective 1D NMR experiment - GEMSTONE-ROESY - enables clear, unambiguous assignment of ROE signals in the not uncommon situation that traditional selective methods fail. Its usefulness is demonstrated in the analysis of the natural products cyclosporin and lacto--difucohexaose I, providing detailed insight into the structures and conformations of these molecules.

摘要

一种超选择性的 1D NMR 实验——GEMSTONE-ROESY——能够在传统选择性方法失败的常见情况下，清晰、明确地分配 ROE 信号。它在天然产物环孢菌素和乳-二岩藻六糖 I 的分析中得到了证明，为这些分子的结构和构象提供了详细的见解。