Liao Xi, Liu Yuwei, Feng Jinhua, Li Ka
Department of Colorectal Cancer, West China Hospital, Sichuan University, Chengdu, 610041.
West China School of Nursing, Sichuan University, Chengdu, 610041.
Zhongguo Yi Liao Qi Xie Za Zhi. 2023 Feb 8;47(2):173-177. doi: 10.3969/j.issn.1671-7104.2023.02.011.
Hyaluronic acid (HA) has favorable physicochemical properties and superior biological activities, which is an ideal biomaterial for preparing hydrogel coating. After physically or chemically modifying, HA-based hydrogel coating has been gradually applied to functional modification for medical catheters surface, such as hydrophilic lubricating coating, anti-inflammatory coating, biomedical antifouling coating and blood compatibility improved coating. However, there are still intractable problems in the coating technology of HA hydrogel which is applied to the surface of medical catheters, especially in adhesion, stability and element proportion of HA coating. Finally, the related influencing factors and improvement suggestions are analyzed in this study.
透明质酸（HA）具有良好的物理化学性质和卓越的生物活性，是制备水凝胶涂层的理想生物材料。经过物理或化学改性后，基于HA的水凝胶涂层已逐渐应用于医用导管表面的功能改性，如亲水性润滑涂层、抗炎涂层、生物医学防污涂层和血液相容性改善涂层。然而，应用于医用导管表面的HA水凝胶涂层技术仍存在一些棘手的问题，特别是在HA涂层的附着力、稳定性和元素比例方面。最后，本研究分析了相关影响因素并提出了改进建议。
