miRNA 26a和26b与基质金属蛋白酶-9的过表达是结直肠癌患者有价值的诊断生物标志物。

Overexpression of miRNA 26a and 26b with MMP-9 are valuable diagnostic biomarkers for colorectal cancer patients.

作者信息

Farouk Sally, El-Shenawy Reem, Khairy Ahmed M, Bader El-Din Noha G

机构信息

Department of Microbial Biotechnology, National Research Centre, Dokki, 12622, Egypt.

Department of Endemic Medicine, Faculty of Medicine, Cairo University, Giza, 11562, Egypt.

出版信息

Biomark Med. 2023 Feb;17(3):159-169. doi: 10.2217/bmm-2022-0861. Epub 2023 Apr 25.

DOI:10.2217/bmm-2022-0861

PMID:37097025

Abstract

The key role of miRNA expression in incidence and progression of colorectal cancer (CLC) have been developed over the last decade. A total of 153 subjects were enrolled into two phases: 14 selected miRNAs were first evaluated in 50 subjects, then miR-26a and miR-26b relative expression were further evaluated in 103 subjects and their target protein MMP-9 was measured. miR-26a and -26b showed highly significant overexpression. Both miR-26a and -26b (p < 0.001) had high diagnostic efficacy for CRC. There was a significant increase in serum MMP-9 protein in CRC patients with positive correlation with miR-26a and -26b expression levels (p < 0.001). miRNA 26a and 26b with MMP-9 can be used as diagnostic biomarker for CRC patients.

摘要

在过去十年中，微小RNA（miRNA）表达在结直肠癌（CLC）的发生和发展中的关键作用已得到深入研究。共有153名受试者参与了两个阶段的研究：首先在50名受试者中评估14种选定的miRNA，然后在103名受试者中进一步评估miR-26a和miR-26b的相对表达，并检测其靶蛋白基质金属蛋白酶-9（MMP-9）。miR-26a和-26b表现出高度显著的过表达。miR-26a和-26b（p < 0.001）对结直肠癌均具有较高的诊断效能。结直肠癌患者血清MMP-9蛋白显著升高，且与miR-26a和-26b表达水平呈正相关（p < 0.001）。miRNA 26a和26b与MMP-9可作为结直肠癌患者的诊断生物标志物。