Kohn Mark D, Wolock Charles J, Poulson Isaac J, Fernando Navin D
Department of Orthopaedic Surgery and Sports Medicine, University of Washington, Seattle, Washington, USA.
Department of Biostatistics, University of Washington, Seattle, Washington, USA.
EFORT Open Rev. 2023 Apr 25;8(4):180-188. doi: 10.1530/EOR-22-0117.
This investigation provides a rigorous systematic review of the postoperative outcomes of patients with and without chronic hepatitis C who underwent total hip arthroplasty (THA) and total knee arthroplasty (TKA).
We queried PubMed, Embase, Cochrane Database of Systematic Reviews, Scopus, Web of Science and the 'gray' literature, including supplemental materials, conference abstracts and proceedings as well as commentary published in various peer-reviewed journals from 1992 to present to evaluate studies that compared the postoperative outcomes of patients with and without chronic hepatitis C who underwent primary THA or TKA. This investigation was registered in the PROSPERO international prospective register of systematic reviews and follows the guidelines provided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. In our literature search, we identified 14 articles that met our inclusion criteria and were included in our fixed-effects meta-analysis. The postoperative outcomes analyzed included periprosthetic joint infection (PJI), aseptic revision, non-homebound discharge and inpatient mortality.
Our statistical analysis demonstrated a statistically significant increase in postoperative complications of patients with chronic hepatitis C who underwent primary THA or TKA including PJI (odds ratio (OR): 1.98, 95% CI: 1.86 - 2.10), aseptic revision (OR: 1.58, 95% CI: 1.50 - 1.67), non-homebound discharge (OR: 1.31, 95% CI: 1.28- 1.34) and inpatient mortality (OR: 9.37, 95% CI: 8.17 - 10.75).
This meta-analysis demonstrated a statistically significant increase in adverse postoperative complications in patients with chronic hepatitis C who underwent primary THA or TKA compared to patients without chronic hepatitis C.
本研究对接受全髋关节置换术（THA）和全膝关节置换术（TKA）的慢性丙型肝炎患者与非慢性丙型肝炎患者的术后结局进行了严格的系统评价。
我们检索了PubMed、Embase、Cochrane系统评价数据库、Scopus、Web of Science以及“灰色”文献，包括补充材料、会议摘要和论文集，以及1992年至今在各种同行评审期刊上发表的评论，以评估比较接受初次THA或TKA的慢性丙型肝炎患者与非慢性丙型肝炎患者术后结局的研究。本研究已在PROSPERO国际系统评价前瞻性注册库中注册，并遵循系统评价和Meta分析的首选报告项目（PRISMA）声明提供的指南。在文献检索中，我们确定了14篇符合纳入标准的文章，并将其纳入固定效应Meta分析。分析的术后结局包括假体周围关节感染（PJI）、无菌性翻修、非居家出院和住院死亡率。
我们的统计分析表明，接受初次THA或TKA的慢性丙型肝炎患者术后并发症在统计学上显著增加，包括PJI（比值比（OR）：1.98，95%置信区间：1.86 - 2.10）、无菌性翻修（OR：1.58，95%置信区间：1.50 - 1.67）、非居家出院（OR：1.31，95%置信区间：1.28 - 1.34）和住院死亡率（OR：9.37，95%置信区间：8.17 - 10.75）。
本Meta分析表明，与非慢性丙型肝炎患者相比，接受初次THA或TKA的慢性丙型肝炎患者术后不良并发症在统计学上显著增加。
