State Key Laboratory of Pulp & Paper Engineering, South China University of Technology, 510640, Guangzhou, China.
Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine, Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, 210023, Jiangsu, China.
Adv Healthc Mater. 2023 Aug;12(21):e2300075. doi: 10.1002/adhm.202300075. Epub 2023 May 10.
Chitin is a popular hemostatic material, but there are still many deficiencies in its ability to effectively stop bleeding, prevent infection, and fit wounds. Herein, AgNP@zeolite/chitin/bamboo (AgZ-CB) composite sponges with shape recovery are prepared to minimize blood loss, kill bacteria, and promote wound healing. Notably, the bamboo powder is used for the first time to remarkably enhance the softness of the composite sponge (volumetric expansion ratio >5). The fabricated AgZ-CB sponge exhibits an excellent killing effect (≈100% bactericidal rate) against both Escherichia coli and Staphylococcus aureus and activates internal and external coagulation pathways to accelerate hemostasis without causing thermal damage (≈5 °C temperature difference). Moreover, the AgZ-CB sponge shows less blood loss (26 mg) and a shorter time to hemostasis (42 s) than the commercial polyvinyl formal sponge (84 mg and 76 s) in the full-thickness liver injury model. The in vivo wound healing and biodegradation experiment indicate that AgZ-CB with excellent biocompatibility can close wounds efficiently. Overall, the AgZ-CB sponge has great potential in combating a series of obstacles in wound healing.
壳聚糖是一种常用的止血材料，但在有效止血、预防感染和适应伤口方面仍存在许多不足。本文制备了具有形状回复能力的载银纳米颗粒沸石/壳聚糖/竹粉（AgZ-CB）复合海绵，以最大程度地减少失血量、杀死细菌和促进伤口愈合。值得注意的是，首次使用竹粉显著提高了复合海绵的柔软度（体积膨胀比>5）。所制备的 AgZ-CB 海绵对大肠杆菌和金黄色葡萄球菌均表现出优异的杀灭效果（≈100%杀菌率），并激活内外凝血途径，加速止血而不会造成热损伤（≈5°C 温差）。此外，AgZ-CB 海绵在全层肝损伤模型中的失血量（26mg）和止血时间（42s）均低于商用聚乙烯醇海绵（84mg 和 76s）。体内伤口愈合和生物降解实验表明，具有优异生物相容性的 AgZ-CB 能够高效闭合伤口。总体而言，AgZ-CB 海绵在克服伤口愈合过程中的一系列障碍方面具有巨大潜力。
